Effect of Anesthesia inducing drugs on blood pressure and heart rate in hypertensive patients.

Not yet recruiting

Conditions: Essential (primary) hypertension,

Registration Number: CTRI/2022/12/047981

Lead Sponsor: AIIMS Raipur

Brief Summary: In the current era anesthesia is required for almost all surgeries that includes amnesia, analgesia, muscle relaxation and homoeostasis. Ideal induction agent for General Anaesthesia should have hemodynamic stability, minimal respiratory side effects, rapid clearance, lack of pain on injection, rapid return of consciousness. Induction is the most stressful moment of general anaesthesia. Commonly used induction agents are propofol, thiopentone, etomidate and ketamine. Increase in hemodynamic instability is more prominent in hypertensive patients, many times profound decrease in BP is observed. Propofol produce nitric oxide and cause bradycardia and hypotension due to reduction in preload and afterload. This study is aimed at comparing haemodynamic responses associated with anaesthetic induction with propofol and sodium thiopentone in hypertensive patients.

Hypertension is an modifiable risk factor cardiovascular morbidity and mortality. Less than half of those who has hypertension are diagnosed with hypertension others are left undiagnosed. Aetiology of hypertension is a complex

interaction between genetic and Pathophysiological mechanisms which involves multiple systems. Both lifestyle modification and pharmacological therapy are effective in lower blood pressure. Hypertension can primary

(essential hypertension) or secondary hypertension.

In this study hemodynamic responses of propofol and thiopentone in hypertensive is compared. Blood pressure, Heart rate and SPO2 will be measured at regular interval after giving anyone of the drugs. These data will be used compared and the efffect of both drug on hemodynamics in hypertensive patient.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 54

Inclusion Criteria

Patients undergoing surgery under general anaesthesia with 1) ASA II or III 2) Male or female 3) Controlled hypertensive patient 4) Duration of surgery more than 30 minutes.

Exclusion Criteria

Patient refusal Allergy to any medication Allergy to egg or soya bean History of ischemic heart disease, myocardial infraction, asthma and diabetes mellitus Any other contraindication for the drugs Difficult airway Obesity.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure values	baseline, 1 minute, 2minute, 3 minute, 4 minute post administration of induction agents and 1 minute, 2 minute, 3 minute, 4 minute, 5 minute, 6 minute, 7 minute, 8 minute, 10 minute, 15 minute, 20 minute, 25 minute, 30 minute after intubation

Secondary Outcome Measures

Name	Time	Method
Best inhalational agent with respect to hemodynamic stability	baseline, 1 minute, 2minute, 3 minute, 4 minute post administration of induction agents and 1 minute, 2 minute, 3 minute, 4 minute, 5 minute, 6 minute, 7 minute, 8 minute, 10 minute, 15 minute, 20 minute, 25 minute, 30 minute after intubation

Trial Locations

Locations (1): AIIMS Raipur
🇮🇳
Raipur, CHHATTISGARH, India
AIIMS Raipur
🇮🇳Raipur, CHHATTISGARH, India
Dr Sangeeth C
Principal investigator
7000529561
mailsangeeth111@gmail.com