EEG investigation of gait and balance in Parkinson*s disease using immersive virtual reality

Completed

Conditions: Parkinson's disease
10028037

Registration Number: NL-OMON40694

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 48

Inclusion Criteria

- Idiopathic Parkinson's disease
- Age between 45 -70 years
- Moderate disease severity (Hoehn-Yahr 2-3)

Exclusion Criteria

- Other neurological or psychiatric conditions, including stroke, traumatic brain injury, epilepsy, depression or anxiety disorder
- Electronic equipment implanted
- Severe visual impairment
- Declining to be informed of medically relevant chance findings in the investigation

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters:<br /><br>- power values of EEG oscillatory activity in different frequency bands<br /><br>- phase relationship of oscillations with external events<br /><br>- phase relationship of oscillations at different frequencies (cross-frequency<br /><br>coupling)<br /><br>- cortical distribution of oscillatory activity </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters:<br /><br>-Gait-coordination parameters i.e. step length, width, symmetry and frequency,<br /><br>relative phase relationship between arms, legs and trunk movements.<br /><br><br /><br>Descriptive study parameters:<br /><br>- Clinical characteristics: Unified Parkinsons Disease Rating Scale,<br /><br>- Walking performance: 10 meter walk test; freezing of Gait Questionnaire<br /><br>- Balance performance: Single leg stance test<br /><br>- Activities of Daily Living: Nottingham Extended ADL Index<br /><br>- Quality of life: Short-form-36; Parkinsons Disease Questionnaire-39</p><br>