Differentiation between normal tissue and malignant tissue with light spectrum analysis.
Completed
- Conditions
- Cancer of breast, lung and liver
- Registration Number
- NL-OMON28806
- Lead Sponsor
- The Netherlands Cancer Institute (NKI-AVL)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 83
Inclusion Criteria
1. Patients with proven malignant lesion of breast, lung or liver or benign fibroadenoma of the breast;
2. In case of breast malignancy: Patients are scheduled for a local resection or for an ablation of the breast;
Exclusion Criteria
1. Patients with no proof of residual malignant disease after neo-adjuvant therapy by follow-up radiological analysis before operation;
2. Patients with suspected sensitivity to light; e.g. patients who have had photodynamic therapy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of Diffuse reflectance parameters (Oxyhaemoglobin saturation, total haemoglobin content, water and fat content, collagen content, B-carotene content within the tissue as well as 3 scatter coefficients of the tissue) and Fluorescence parameters (Collagen, elastin, NADH content) within the tissue.<br /> <br>Comparison will be made with Pathology parameters (histology characteristics of the tissue, tumor grade, percentage necrosis) as golden standard.
- Secondary Outcome Measures
Name Time Method