comparison between different combination of drugs such 0.75% Ropivacaine fentanyl and 0.75% ropivacaine , fentanyl and magnesium sulphate in epidural anesthesia in lower limb surgeries
Phase 4
Completed
- Conditions
- Health Condition 1: null- ASA Grade II or III individuals being posted for elective lower limb surgeries
- Registration Number
- CTRI/2018/01/011315
- Lead Sponsor
- Department of anesthesiology King Georges Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
A total of 60 patients of either sexes, age group between 18-65 yrs, body weight between 40-80 Kg and ASA grade I&II were chosen surgerieswho were posted for elected lower limb
Exclusion Criteria
Patients of renal, pulmonary, cardiovascular, neurological, neuromuscular diseases deranged liver function test were excluded from our study. Any contraindication to epidural anesthesia as local site infection, bleeding tendencies, vertebral anomalies, Sepsis, Raised Intracranial pressure, allergy to local anesthetic agents, peripheral neuropathy, patientâ??s refusal and physical dependence on narcotics were also excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method when mgso4 added to 0.75% Ropivacaine and fentanyl for epidural anesthesia, it brings about better quality, faster onset, and longer duration of sensory and motor blockade when compared with ropivaCaine fentanyl aloneTimepoint: variables block characteristics such as:-Time for achieving onset of analgesia, Time for achieving T10 sensory blockade ,Median and maximum level of sensory blockade achieved, Time for achieving Motor Blockade ,Time for complete motor recovery ,Time for requirement of first epidural top up from initial medication (in min)
- Secondary Outcome Measures
Name Time Method better hemodynamic and side effect profile with 0.75% ropivacaine fentanyl and mgso4 than with ropivacaine and fentanyl in epidural anesthesiaTimepoint: mean arterial pressure heart rate and spo2 was observed at preoperatively 0, 5, 10,15,20, 30 ,45,60,90,120,150,180,210,240 minutes till the end of surgery and postoperatively while shifting the patient.side effect profile was checked at all time intervals after administering the drug to the patient.