The Effects of Resistance Training With Hydrolyzed Collagen Supplementation on Muscle and Tendon Adaptation in Healthy Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Patellar tendon cross-sectional area
研究概览
简要总结
The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.
The main questions it aims to answer are:
- Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone?
- Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?
Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups.
Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.
详细描述
Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks.
The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance.
The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy young male or female
- •No history of patellar tendon injuries in the past 6 months
- •No history of lower limb musculoskeletal injuries in the past 6 months
- •Non-smokers (including e-cigarettes)
- •Free from cardiovascular and metabolic diseases
- •Nullipara (a woman who has never given birth)
排除标准
- •Age less than 18 years or higher than 40 years
- •Being vegan or vegetarian (due to the mammalian source of collagen)
- •Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
- •BMI over 30 kg/m2
- •Previous anterior cruciate ligament injury where the patellar tendon was used as a graft
结局指标
主要结局
Patellar tendon cross-sectional area
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured.
Patellar tendon stiffness
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured.
Maximal knee extensor (quadriceps) muscle strength
时间窗: 12 weeks (10 weeks' intervention plus one week either side for assessments)
Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
Maximal knee flexor (hamstring) muscle strength
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
Vastus lateralis (VL) muscle fascicle pennation angle
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured.
Vastus lateralis (VL) muscle size
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured.
Vastus lateralis (VL) muscle fascicle length
时间窗: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured.
次要结局
未报告次要终点