Effects of paracetamol use on the immune response after hepatitis B vaccinatio

Withdrawn

• Conditions: nvt; vaccinatierespons; er wordt geen aandoening bestudeerd

• Registration Number: NL-OMON36173
• Lead Sponsor: RIVM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 276

Inclusion Criteria

- Good health.
- Able to perform the study according to the procedures.
- Informed consent present.

Exclusion Criteria

- History of acute or chronic hepatitis B
- Earlier hepatitis B vaccination
- Evidence of a serious disease, that needs immunosuppresive treatment.
- A known primary or secondary immunodeficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Antibody concentrations prior to and 1 month after the third vaccination<br /><br>(booster vaccination) will be measured. Antibody concentrations expected to be<br /><br>lower in participants that used paracetamol prophylactically. The titers in<br /><br>the groups treated therapeutically with paracetamol cannot be predicted and<br /><br>are subject of this study.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Alterations in the functionality of specific lymfocyte subpopulations in blood<br /><br>of participants that used paracetamol prophylactically. </p><br>