Can paracetamol alter thermoregulatory responses to exercise in healthy volunteers?

Recruiting

• Conditions: hyperthermie (inspanningsgerelateerd); hyperthermia

• Registration Number: NL-OMON36074
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• Age : 18-45 years
• Willing to sign informed consent
• Healthy

Exclusion Criteria

- hypersensitivity or idiosyncratic reaction to paracetamol.
- pregnant or lactating women.
- hepatic and/or renal impairment from participation.
- Because of potential interaction with other medication, we will exclude subjects with cholestyramine (which reduced the absorption speed of paracetamol), metoclopramide or domperidone (which speed of absorption of paracetamol is increased), warfarin (increased risk of bleeding) or chloramphenicol (increased plasma levels of chloramphenicol).
- obstructive disease of the gastro-intestinal tract (including diverticulitis and inflammatory bowel disease or previous gastrointestinal surgery, except cholecystectomy and appendectomy)
- subjects that will undergo a MRI-scan within 2 days after one of the testing days
- subjects with a cardiac pacemaker or other implanted electromedical devices
- As subjects will be performing a submaximal cycling test, we will also exclude:
• Hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg)
• Any cardiovascular abnormality in past medical history, physical examination or ECG, including prolonged QTc interval.
• BMI>=30 kg/m2
• Inability to perform bicycle exercise
• The presence of an absolute or relative contra-indication for exercise testing

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified