Efficacy and safety of albendazole-oxantel combined and single oxantel albendazole, and mebendazole, in the treatment of Trichuris trichiura and hookworm infections in Pemba: a randomized, double blind trial

Medicor Foundation (Liechtenstein)0 个研究点目标入组 650 人开始时间: 2012年8月22日最近更新: 2015年1月13日

适应症

试验速览

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•1. Written informed consent signed by parents and/or legal guardian; and oral assent by children
•2. Able and willing to be examined by a study physician at the beginning and at the end of the study (3 weeks post-treatment)
•3. Able and willing to provide two stool samples at the beginning and at the end of the study
•4. Positive for T. trichiura or hookworm, or both STH concurrently (presence of helminth eggs in stool)
•5. Absence of major systemic illnesses (e.g. cancer, diabetes, clinical malaria or hepato-splenic schistosomiasis) as assessed by a medical doctor, upon initial clinical assessment
•6. No known or reported history of chronic illness such as cancer, diabetes, chronic heart, liver or renal disease
•7. No recent anthelminthic treatment (within past 4 weeks)
•8. No known allergy to study medications

•1. No written informed consent by parents and/or legal guardian
•2. Presence of any abnormal medical condition, judged by the study physician
•3. History of acute or severe chronic disease such as cancer, diabetes, chronic heart, liver or renal disease
•4. Recent use of anthelminthic drug (within past 4 weeks)
•5. Attending other clinical trials during the study
•6. Negative diagnostic result for T. trichiura and/or hookworm (absence of helminth eggs in stool)

发起方

Medicor Foundation (Liechtenstein)