Efficacy and safety of albendazole-OXantel pamoate, albendazole-mebendazole, albendazole-IVermectin and single MEBendazole in the treatment of Trichuris trichiura and concomitant Soil-Transmitted Helminth infections in Pemba: a randomized controlled trial

Swiss Tropical and Public Health Institute (Switzerland)0 个研究点目标入组 440 人开始时间: 2013年8月1日最近更新: 2016年11月28日

适应症

试验速览

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•1. Written informed consent signed by parents and/or legal guardian; and oral assent by children (aged 6-14 years)
•2. Able and willing to be examined by a study physician and answer a questionnaire about signs and symptoms at the beginning of the study, 3 weeks and 3 months after treatment
•3. Able and willing to provide two stool samples at the beginning of the study, 3 weeks and 3 months after treatment
•4. Able and willing to provide a urine sample and a finger prick blood sample before treatment and 3 months after treatment
•5. Positive for T. trichiura (presence of eggs in stool) at the baseline parasitology survey
•6. Absence of major systemic illnesses (e.g. clinical malaria or hepato-splenic schistosomiasis) as assessed by a medical doctor, upon initial clinical assessment
•7. No known or reported history of chronic illness such as cancer, diabetes, heart, liver or renal disease
•8. No known allergy to study medications

•1. No written informed consent by parents and/or legal guardian
•2. Presence of any abnormal medical condition, judged by the study physician
•3. History of acute or severe chronic disease such as cancer, diabetes, chronic heart, liver or renal disease.
•4. Recent use of anthelminthic drugs (within the past 4 weeks)
•5. Attending other clinical trials during the study
•6. Negative diagnostic result for T. trichiura (absence of eggs in stool) at baseline parasitological survey

发起方

Swiss Tropical and Public Health Institute (Switzerland)