Impact of Comprehensive Rehabilitation Nursing Combined With Refined Airway Management and Nutritional Support on Prognosis and Care Delivery Models in Critically Ill Patients

Not Applicable

Completed

• Conditions: Critically Ill Patients; Nutritional Support; Pulmonary Infections; Gastrointestinal Bleeding; Acute Kidney Injury (AKI)

• Registration Number: NCT07025941
• Lead Sponsor: Taizhou Hospital of Traditional Chinese Medicine

Brief Summary

This combined intervention protocol effectively improves the prognosis of critically ill patients and optimizes nursing management models

Detailed Description

To investigate the impact of comprehensive rehabilitation nursing combined with refined airway management and nutritional support on the prognosis of critically ill patients and nursing management models, and to develop a new care management protocol. Critically ill patients were divided into a control group (routine nursing) and an intervention group (comprehensive rehabilitation nursing combined with refined airway management and nutritional support). Complications such as pulmonary infection and gastrointestinal bleeding, as well as clinical indicators including oxygen saturation (SpO₂), mechanical ventilation time (MVT), and length of stay (LOS), were compared between the two groups. Logistic regression and XGBoost models were constructed to analyze key influencing factors.

Study Timeline

• Study Start: 2023-06-02
• Primary Completion: 2024-06-05
• Study Completion: 2024-06-23
• Status Verified: 2025-06
• Study First Submitted: 2025-06-09
• Study First Submitted QC: 2025-06-17
• Last Update Submitted: 2025-06-17
• Study First Posted: 2025-06-18
• Last Update Posted: 2025-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• Fulfillment of ICU admission standards with critical illness confirmed by attending physicians or senior specialists
• Age ≥ 18 years
• Stable vital signs:

Systolic blood pressure ≥ 90 mmHg and ≤ 180 mmHg

Heart rate ≤ 120 beats/min

Oxygen saturation (SpO₂) ≥ 85% under ≤ 60% fraction of inspired oxygen (FiO₂)

• Intact or tolerable gastrointestinal (GI) function for enteral nutrition
• Informed consent from both patients and families

Exclusion Criteria

(1)

• Terminal malignancies
• Brain death
• Irreversible organ failure (e.g., end-stage cirrhosis, advanced heart failure)
• Comorbidities potentially confounding study outcomes
• Contraindications to interventions (e.g., laryngeal edema, complete intestinal obstruction)
• Pregnancy or lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
ICU Length of Stay (LOS)	From randomization to ICU discharge, up to 60 days	Calendar days from ICU admission to discharge criteria met (APACHE II score ≤10, hemodynamic stability for ≥24h).

Secondary Outcome Measures

Name	Time	Method
Incidence of Pulmonary Infections	From ICU admission to 48 hours post-extubation or 14-day intervention period	Rate of ventilator-associated pneumonia (VAP) and other pulmonary infections confirmed by clinical criteria (temperature \>38°C or \<36°C, purulent secretions, leukocytosis \>10×10⁹/L or leukopenia \<4×10⁹/L) plus microbiological evidence from sputum/BALF cultures.

Trial Locations

Locations (1)

Taizhou Hospital of Traditional Chinese Medicine; 🇨🇳 Taizhou, Jiangsu, China