Effects of a short-term high protein diet on protein metabolism and physical stress response in children after cardiac surgery.

• Conditions: cardiac surgery, protein energy malnutrition, stress response; hartchirurgie, eiwitondervoeding, stressreactie

• Registration Number: NL-OMON28280
• Lead Sponsor: MC Leiden

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

1. Congenital heart disease (tricuspid valve atresia, pulmonary atresia, right ventricular hypoplasia) with planned surgical Glenn or Fontan procedure;

2. Extra-corporeal circuit during surgery;

Exclusion Criteria

1. Prematurity < 37 weeks;

2. Diabetes mellitus;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Total body Ra [1-13C]valine;<br /><br>2. Total body valine oxidation;<br /><br>3. Nonoxidative disposal valine;<br /><br>4. Dndogenous Ra [1-13C]valine;<br /><br>5. Valine balance;<br /><br>6. Ra [15N2]urea in plasma;<br /><br>7. Whole body net nitrogen retention.

Secondary Outcome Measures

Name	Time	Method
Serum concentrations of:<br /><br>1. Insulin;<br /><br>2. Glucose;<br /><br>3. Cortisol;<br /><br>4. CBG;<br /><br>5. IL 6-8-10;<br /><br>6. CRP;<br /><br>7. TNF-á.