Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers: The INDAGA-UK Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 250
- 主要终点
- • Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.
研究概览
简要总结
The INDAGA-UK trial is a retrospective, multi-centre observational study in participants with locally advanced and recurrent salivary gland to investigate t its molecular profiling, and to explore new prognostic and druggable markers. We will analyse samples and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and sample identification will occur over a 12-month period. Samples and data will be analysed over the next 12 months prior to study end.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged over 18
- •Histological diagnosis of salivary gland cancer (SGCs)
- •Availability of archival tissue (acceptable after 2013 up to present)
- •Ability to give informed consent (if applicable)* for retrieving histological specimen and preform molecular analysis *De-identified archival tissue from deceased patients will be collected as part of the study once REC approval is in place, if the patient was alive when the samples were taken and they are not part of the NHS opt out scheme.
排除标准
- •Different H&N cancer of other histology
- •Thyroid cancers
结局指标
主要结局
• Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.
时间窗: Time Frame: Through study completion, expected duration of 10 years
• Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.
次要结局
未报告次要终点