Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Completed

• Conditions: Healthy

• Registration Number: NCT04618302
• Lead Sponsor: Thomas Radtke

Brief Summary

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Detailed Description

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Study Timeline

• Study Start: 2020-10-19
• Study First Submitted: 2020-10-28
• Study First Submitted QC: 2020-11-04
• Study First Posted: 2020-11-05
• Primary Completion: 2020-12-31
• Study Completion: 2021-01-01
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-15
• Last Update Posted: 2021-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• Healthy
• Age 18 yrs and older
• Ability to follow study procedures and instructions in German

Exclusion Criteria

• Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
• Obesity (BMI > 30kg/m2)
• Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
• Mental impairment leading to inability to cooperate
• Respiratory infection in the last two weeks
• Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diffusing capacity for nitric oxide (DLNO)	At third study visit, approximately 1-2 weeks after second study visit	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Secondary Outcome Measures

Name	Time	Method
Alveolar volume (VA)	At third study visit, approximately 1-2 weeks after second study visit	Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.
Diffusing capacity for carbon monoxide (DLCO)	At third study visit, approximately 1-2 weeks after second study visit	Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.
Diffusing capacity for nitric oxide (DLNO)	At third study visit, approximately 1-2 weeks after second study visit	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.
Breath hold time (BHT)	At third study visit, approximately 1-2 weeks after second study visit	BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.

Trial Locations

Locations (1)

University of Zurich and University Hospital of Zurich; 🇨🇭 Zurich, Switzerland