Efficacy of Non Contrast DWI(Diffusion Weighted Imaging) Imaging Compared to DMR-DE

Not Applicable

Completed

• Conditions: Heart Attack
• Interventions: Procedure: Diffusion Weighted Imaging with MRI scans

• Registration Number: NCT01820000
• Lead Sponsor: University of Michigan

Brief Summary

Use of MRI and DWI to diagnose cardiac scarring after heart attack.

Detailed Description

To discover new information about MRI (magnetic resonance imaging) called DWI (diffusion weighted imaging) and its ability to diagnose cardiac scarring.

CMR-DE (cardiac MR with delayed contrast enhancement) evaluates if there has been scarring in the heart muscle following a heart attack.

Subjects are injected with a contrast medication that makes the scarring visible if present. To prove the efficacy of DWI (diffusion weighted imaging) to provide the same images that CMR-DE (cardiac magnetic resonance with delayed contrast enhancement) provides.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2013-02-05
• Study First Submitted QC: 2013-03-22
• Study First Posted: 2013-03-28
• Primary Completion: 2014-09
• Study Completion: 2016-07
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-18
• Last Update Posted: 2016-10-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Males and females 21 years of age and older
• Healthy volunteers
• subjects with a prior history of heart attack and prior CMR-DE imaging.

Read More

Exclusion Criteria

• Women who are pregnant
• Subjects with GFR < 60 ml/min/1.73m2
• Subjects with ICD
• Subjects with coronary stents incompatible with 3T

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Diffusion Weighted Imaging with MRI scans	Diffusion Weighted Imaging with MRI scans	Subjects will undergo a MRI (magnetic resonance imaging) scan where DWI (diffusion weighted imaging) will be performed. Subjects will not receive contrast during this sequence, but will receive contrast as standard MRI protocol.

Primary Outcome Measures

Name	Time	Method
presence and apparent diffusion coefficient (ADC) quantification of scar on (DWI) diffusion weighted image	single occurance	Confirm the efficacy of diffusion weighted imaging in providing imaging that shows cardiac scarring without the injection of contrast.

Trial Locations

Locations (1)

University of Michigan Hospital; 🇺🇸 Ann Arbor, Michigan, United States