Medication Optimisation for Reducing Events in a Private Practice Setting
- Conditions
- Pharmacogenetic Analysis to Reduce Events.
- Registration Number
- NCT00653653
- Lead Sponsor
- Awenydd GmbH
- Brief Summary
Using a prospective study design of two three month periods (before and after genotyping) in which the patients will self-monitor their health status and possible medical events it is hypothesized that it will be shown that patients having their medication altered to fit their genetic status and/or having their medication altered because of inherent interaction potential will have less recordable events after genotyping and medical analysis than before.
It is well known that ADRs (recordable adverse events to medication) are responsible for a large number of deaths and hospitalizations. Furthermore it is well recorded that genotyping of individual cytochrome P450 enzymes (2D6, 2C9, 2C19, among others) is directly related to a metabolic phenotype - fast metabolisers, slow metabolisers, intermediate and normal metabolisers. These differing phenotypes have altered metabolism of many medications and in a number of retrospective clinical trails it has been shown that ADRs and effect can be reduced/bettered through genotyping and alteration of medication.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
- older than 18 years
- not demented
- 1 or more documented events in the previous 6 months.
- more than one medication
- multi-morbid
- demented
- life expectancy less than 1 year
- heart attack within the last 6 months
- Marcumar® Therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of reported events in the time frame. 3 months
- Secondary Outcome Measures
Name Time Method Reduction of total costs associated per patient in the time frame. 3 months
Trial Locations
- Locations (1)
Awenydd Gmbh
🇩🇪Köln, NRW, Germany