Exercise Training and Testosterone Replacement in Heart Failure Patients
Overview
- Phase
- Phase 4
- Intervention
- Exercise training
- Conditions
- Heart Failure
- Sponsor
- University of Sao Paulo General Hospital
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- Microneurography
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine if exercise training with or without testosterone replacement can improve cardiopathy in heart failure patients
Detailed Description
In this study, we are evaluating: * hospital length of stay and readmission * muscle sympathetic nerve activity * functional capacity * body composition
Investigators
Eligibility Criteria
Inclusion Criteria
- •heart failure
- •hypogonadism
- •left ventricular fraction ejection \< 45%
Exclusion Criteria
- •chronic renal failure
- •normal testosterone
- •pace maker
Arms & Interventions
Exercise training
Aerobic and strength exercise training
Intervention: Exercise training
Testosterone replacement
Testosterone replacement will be done quarterly
Intervention: Testosterone replacement
Testosterone replacement+Exercise
Both Testosterone replacement and Exercise will done
Intervention: Testosterone replacement
Testosterone replacement+Exercise
Both Testosterone replacement and Exercise will done
Intervention: Exercise training
Outcomes
Primary Outcomes
Microneurography
Time Frame: 4 months of exercise training/testosterone replacement
Muscle sympathetic nerve activity (MSNA) is recorded directly from the peroneal nerve using the microneurography technique. Multiunit postganglionic muscle sympathetic nerve recordings is made using a tungsten microelectrode. All of the recordings of MSNA met previously established and described criteria. MSNA is quantified as burst frequency (bursts per minute).
Forearm blood flow
Time Frame: 4 months of exercise training/testosterone replacement
Forearm blood flow is measured by venous occlusion plethysmography. The nondominant arm is elevated above heart level to ensure adequate venous drainage. A mercury-filled silastic tube attached to a low-pressure transducer is placed around the forearm and connected to a plethysmography. Forearm blood flow is determined on the basis of a minimum off four separate readings. Forearm vascular conductance is calculated by dividing forearm blood flow by mean arterial pressure times 100 and expressed in arbitrary units.
Secondary Outcomes
- Cardiopulmonary exercise(4 months of exercise training/testosterone replacement)
- Body composition(4 months of exercise training/testosterone replacement)
- Muscle biopsy(4 months of exercise training/testosterone replacement)