EUCTR2006-001090-23-GB
Active, not recruiting
Phase 1
Testosterone therapy as an adjunct to exercise rehabilitation: effects on exercise capacity, inflammatory markers and quality of life in hypogonadal males with chronic heart failure. - none
ConditionsCongestive heart failure
DrugsSustanon 250
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Congestive heart failure
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
- Status
- Active, not recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Symptoms of hypogonadism
- •Blood testosterone level of up to 15 nmol.l\-1
- •Clinically stable CHF (longer than 6 months, prior to recruitment)
- •Evidence of impairment of left ventricular systolic function (defined by echocardiography as ejection fraction less than 35%)
- •Reduced exercise tolerance (limited by fatigue or breathlessness of cardiac origin)
- •Patients must be over 18 years of age
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range
Exclusion Criteria
- •Unstable angina
- •Recent acute myocardial infarction
- •Decompensated heart failure
- •Haemodynamically significant valvular heart disease
- •Uncontrolled hypertension
- •Renal insufficiency (serum creatinine \>200umol/l)
- •Urologic disorders
- •Any orthopaedic or neurologic illness limiting the ability to exercise
- •Patients with prostate specific antigen (PSA) level above the age adjusted normal range will also be excluded
- •Patients taking sex hormone therapy
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Testosterone therapy as an adjunct to exercise rehabilitation: effects on exercise capacity, inflammatory markers and quality of life in hypogonadal males with chronic heart failureHypogonadal males with chronic heart failureCirculatory SystemISRCTN99667121Heart Research (UK)36
Completed
Not Applicable
Testosterone supplementation combined with exercise program to improve muscle condition in men affected by inclusion body myositis.Inclusion Body MyositisMusculoskeletal - Other muscular and skeletal disordersInflammatory and Immune System - Other inflammatory or immune system disordersACTRN12618000755235Perron Institute for Neurological and Translational Science15
Completed
Phase 4
Exercise Training and Testosterone Replacement in Heart Failure PatientsHeart FailureNCT01852994University of Sao Paulo General Hospital39
Completed
Phase 3
Effects of testosterone and exercise (TEX) on fitness, physical activity and vascular health in men.ACTRN12615000600549Dr Bu Yeap80
Completed
Phase 3
Starting a Testosterone and Exercise Program After Hip InjuryHip FractureFrailtySarcopeniaNCT02938923Washington University School of Medicine129