Testosterone plus exercise to improve muscle strength and performance in men affected by inclusion body myositis (IBM).

Perron Institute for Neurological and Translational Science0 个研究点目标入组 15 人开始时间: 2018年5月4日最近更新: 2021年3月16日

研究概览

暂无简介。

•Adult men with a diagnosis of IBM in accordance with the ENMC criteria 2011 who are
•able to provide informed consent.
•Inclusion criterion for the extension study:
•*Completion of the first 26 week phase of the study.

•- Active cardiovascular disease (unstable angina, myocardial infarction, stroke, transient
•ischaemic attack, or revascularisation procedure within the past 12 months)
•- History of prostate cancer or other major medical comorbidity (e.g. advanced lung disease or cancer)
•- Men on anti-androgen drugs for benign prostatic hyperplasia (BPH)
•- Elevated blood pressure ( >160 mmHg systolic and > 100 mmHg diastolic)
•- Abnormal prostate examinations suspicious for malignancy
•- Total cholesterol > 6.5 mmol/L or LDL > 4.0 mmol/L
•- eGFR <45 ml/min
•- Testosterone concentration must be in the 5-14 nmol/L range with non-elevated haematocrit and PSA. Men with Testosterone concentration <5 nmol/L would be referred for endocrine assessment, and can participate if no pituitary or testicular disease is found.

发起方

Perron Institute for Neurological and Translational Science