A feasibility study of magnetic stimulation (using TMS - Transcranial Magnetic Stimulation) of the brain to improve limb weakness in motor conversion (functional neurological) disorder disorder
- Conditions
- Motor conversion (functional neurological) disorderNervous System Diseases
- Registration Number
- ISRCTN51225587
- Lead Sponsor
- King's College London
- Brief Summary
2020 results in https://pubmed.ncbi.nlm.nih.gov/33028550/ (added 15/10/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 22
1. DSM5 diagnosis of motor conversion disorder made by consultant neurologist and/or neuropsychiatrist, causing weakness of at least one limb
2. Age =18 years
3. Ability to give written informed consent
1. Epilepsy (or considered high risk of epilepsy from medical history)
2. Other contraindication to TMS (e.g. cochlear implants, metallic intracranial clips or intracranial surgery in last 12 months)
3. Comorbid organic neurological condition
4. Pain as primary symptom
5. Previous treatment with TMS (for any condition)
6. Non-fluent English speakers (if unable to accurately complete self-report questionnaires).
7. Major mental health disorder: current +/- previous diagnosis of schizophrenia or bipolar disorder; current drug/alcohol dependence
8. History of factitious disorder
9. Currently involved in another trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Patient reported changes in symptoms measured using the patient-rated Clinical Global Impression of Improvement scale (CGI-I) at TMS session 1, TMS session 2 and at follow-up.<br>
- Secondary Outcome Measures
Name Time Method