Influence of the Prone Position on Mechanical Power Applied to Respiratory System: Multi-centric Descriptive Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Mechanical power of the respiratory system measured in supine compared with prone position while maintaining the same ventilatory setting
研究概览
简要总结
The primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning while mantaining the same ventilatory setting.
The secondary objetive of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning and adjusting an individualized ventilatory setting.
详细描述
Data of mechanical power will be collected prospectively in three different times:
- In supine positioning (T0).
- After 15 minutes of having implemented prone positioning while maintaining the same ventilatory settings that in supine (T1).
- In prone positioning after 15 min of having adjusted an individualized ventilatory setting (T2).
Besides, the investigators will take an arterial blood sample in T0 and T2 to calculate changes in oxygenation status and ventilatory ratio.
In case that esophageal manometry is available, the investigators will collect data regarding to transpulmonary and esophageal pressure in order to calculate the mechanical power applied to the lung parenchyma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged older than 18 years old under invasive mechanical ventilation with diagnostic criteria of acute respiratory distress syndrome acording to berlin definition and neccesity of prone positioning.
排除标准
- •Need to interrump prone positioning maneuver.
- •Inability to collect data for any reason.
结局指标
主要结局
Mechanical power of the respiratory system measured in supine compared with prone position while maintaining the same ventilatory setting
时间窗: 1) Supine position; 2) Prone position, after 15 min
Mechanical power measured in Joules/min
次要结局
- Mechanical power of the respiratory system measured in supine compared with prone position after adjusting the ventilatory setting(1) Supine position; 2) Prone position, after 15 min of adjusting ventilatory setting.)
研究者
Matias Accoce
Head of respiratory therapists
Sanatorio Anchorena San Martin