Cluster-Randomized Controlled Trial of Hospitals to Reduce Healthcare-Associated Infections and Readmissions Through Routine Bathing With Antiseptic Soap and Targeted Use of Nasal Antibiotic Ointment (ABATE Infection Trial)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 104
- 主要终点
- MRSA and VRE Clinical Cultures
研究概览
简要总结
The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:
- Arm 1: Routine Care Routine policy for showering/bathing
- Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen
Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All HCA hospitals that reside in the United States
- •Note: Unit of randomization is the hospital, but the participants are hospital units
排除标准
- •Non-critical care units where chlorhexidine bathing or decolonization for MRSA+ non-critical care patients is routine
- •Pediatric, peri-partum, rehabilitation, psychiatry, and BMT units
- •Units with >30% cardiac or hip/knee orthopedic surgeries
- •Unit average length of stay <2 days
- •Patients <12 years-old
- •Patients with known allergy to mupirocin or chlorhexidine
结局指标
主要结局
MRSA and VRE Clinical Cultures
时间窗: 21 months
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) clinical cultures attributable to participating units. Defined as occurring \>2 days into a participating unit stay through 2 days following unit discharge
次要结局
- Gram-negative Multi-drug Resistant Organism Clinical Cultures(21 months)
- All-cause Bloodstream Infections(21 months)
研究者
Susan Huang
Associate Professor and Medical Director of Epidemiology and Infection Prevention
University of California, Irvine