on-interventional study to determine platelet reactivity in patients with STEMI / NSTE-ACS and percutaneous coronary revascularization on treatment with P2Y12 receptor antagonists

• Conditions: I20.0; I21.0; I21.1; I21.2; I21.3; I21.4; Unstable angina; Acute transmural myocardial infarction of anterior wall; Acute transmural myocardial infarction of inferior wall; Acute transmural myocardial infarction of other sites

• Registration Number: DRKS00004274
• Lead Sponsor: niversitäts-Herzzentrum Freiburg - Bad Krozingen, Klinik für Kardiologie und Angiologie II

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Are at least 18 years of age - Subjects with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation acute coronary syndrome (NSTE-ACS) admitted at Universitäts-Herzzentrum Freiburg-Bad Krozingen at Bad Krozingen - Indication for urgent percutaneous coronary revascularization

Exclusion Criteria

- Medical or mental condition preventing to provide written informed consent - Acute clinical relevant bleeding - Treatment with a GP IIb/IIIa inhibitor wihin one week prior or during PCI

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelet reactivity (PRU) at PCI determined by VerifyNow P2Y12 assay

Secondary Outcome Measures

Name	Time	Method
Platelet reactivity at PCI and at day 1 after PCI determined by light transmission aggregometry Platelet reactivity at PCI and at day 1 after PCI determined by impedance aggregometry (MEIA test) Platelet reactivity at day 1 after PCI determined by VerifyNow P2Y12 assay