The anti-endotoxin agent, taurolidine, potentially reduces ischaemia-reperfusion injury through its metabolite taurine
- Conditions
- Ischaemia-reperfusion injuryInjury, Occupational Diseases, PoisoningComplications following infusion, transfusion and therapeutic injection
- Registration Number
- ISRCTN58678663
- Lead Sponsor
- Cork University Hospital (Ireland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1. Patients (aged greater than or equal to 18 years, either sex) undergoing elective coronary artery bypass grafting
2. Left ventricular ejection fraction greater than 30% (affects likelihood of developing infection post-operatively for various reasons including increased inotropic support requirements, longer intensive care unit [ICU] stay, delayed mobilisation, and delayed removal of urinary catheters and intravenous lines)
3. Normal pulmonary function tests (affects likelihood of developing respiratory complications post-operatively)
1. Patients with diabetes mellitus (affects likelihood of developing infection post-operatively)
2. Patients taking angiotensin-converting enzyme inhibitors (affects potential to reduce reperfusion injury by acting on leukocytes)
3. Patients taking steroids (more prone to developing infection)
4. Patients with chronic arrhythmias
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10), measured immediately pre-operatively, at aortic unclamping, two, six and 24-hours post-unclamping
- Secondary Outcome Measures
Name Time Method 1. CD11b and CD14 receptor expression, measured immediately pre-operatively, at aortic unclamping, two, six and 24-hours post-unclamping<br>2. Respiratory burst and phagocytosis of circulating neutrophils, measured immediately pre-operatively, at aortic unclamping, two, six and 24-hours post-unclamping<br>3. Plasma lipopolysaccharide (LPS), measured immediately pre-operatively, at aortic unclamping, two, six and 24-hours post-unclamping<br>4. Arrhythmias, analysed intra-operatively and daily up until hospital discharge<br>5. Complications, analysed intra-operatively and daily up until hospital discharge