Effects of exercise intensity on non-motor symptoms in early Parkinson’s disease: randomized, controlled, single-blinded, pilot study

Not Applicable

Completed

• Conditions: Diseases of the nervous system

• Registration Number: KCT0007130
• Lead Sponsor: Inha University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-12-25
• Last Update Posted: 1 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

1) Patients who were diagnosed with Parkinson's disease based on the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria
2) Patients who were aged between 50 and 80
3) Patients with Hoehn and Yahr stage 1 or 2
4) Patients with the disease duration of less than 5 years
5) Patients who had a score = 1 in the MDS-UPDRS part 1
6) Patients who did less than the recommended aerobic exercise proposed by the American College of Sports Medicine (ACSM) (ex. vigorous exercise done <3 times per week, 20 min per session; or moderate exercise done <5 times per week, 30 min per session)
7) Patients who were on stable dopaminergic pharmacotherapy over more than 3 months

Exclusion Criteria

1) Patients with neurological, orthopedic, or cardiac comorbidities that make them unfit to do aerobic exercise
2) Patients who were unable to complete questionnaires due to cognitive impairment
3) Patients on antipsychotics
4) Patients who have symptoms or signs suggesting atypical or secondary parkinsonism (ex. cerebellar signs, supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs; multiple strokes with stepwise progression of symptoms)
5) Patients who were unavailable for more than 10% of the study period

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in scores of the Non-Motor Symptoms Scale

Secondary Outcome Measures

Name	Time	Method
Change in scores of the Montreal Cognitive Assessment;Change in scores of the Beck Depression Inventory;Change in scores of the Apathy Scale ;Change in scores of the Beck Anxiety Inventory;Change in scores of the Pittsburgh Sleep Quality Index;Change in scores of the Epworth Sleepiness Scale ;Change in scores of the RBD screening questionnaire ;Change in scores of the Scales for Outcomes in Parkinson's Disease - Autonomic ;Change in scores of the Parkinson Fatigue Scale ;Change in scores of the King's Parkinson's Disease Pain Scale ;Change in scores of the Parkinson's Disease Questionnaire-39;Change in scores of the MDS-UPDRS part 3 ;Change in maximal aerobic power (V?o2max)