Impact of physical exercise on neuropathic symptoms in cancer patients

Not Applicable

• Conditions: Patienten mit Polyneuropathie; C00-C97; G60-G64; Malignant neoplasms; Polyneuropathies and other disorders of the peripheral nervous system

• Registration Number: DRKS00005419
• Lead Sponsor: niversitätsklinik Freiburg, Klinik für Innere Medizin I, Schwerpunkt Hämatologie, Onkologie und Stammzelltransplantation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-19
• Study Completion: 2015-05-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients with haematological/oncological malignancies and symptoms of PNP regardless
their malignant underlying disease
- Completed chemotherapy
- Age =18 years
- Performance- Status Karnofsky- Index >60
- Signed informed consent
- Geographical proximity (<90 Minutes with transport)

Exclusion Criteria

Absolute:
- Instable bone metastases
- Myocardial infarction, Angina pectoris or heart disease (NYHA III-IV) in a time period of six
months
- Arterial hypertension, which is not treated adequately (in therapy >180mmHg systolic;
>100mmHg diastolic)
- Patients with an increased risk for thrombosis besides underlying disease
- Pregnancy
Relative (inclusion or continuation after recovery possible):
- Acute infection (=38,0°Celcius and/ or intravenously therapy with antibiotics)
- Thrombocytes < 10x109/l
- Leukocytes < 1x109/l

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change (%) of sway path (cm) of CoF (=centre of force) [force plate] <br>To be measured at all three measurement-times: T0 (baseline), T1 (after 12 weeks intervention), and T2 (after 12 weeks follow-up).

Secondary Outcome Measures

Name	Time	Method
The following secondary endpoints are messured at all three messurement-points (T0 (baseline), T1 (after 12 weeks intervention), and T2 (after 12 weeks follow-up)):<br>- Body sway path (cm) and velocity (mm/s) [opto-electric system and a force plate]<br>- Chair-rising test (sec) [force plate]<br>- Nerve conduction velocity (m/s) and amplitude (mm) of stimulus response [neurography]<br>- Patellar and Achilles tendon reflex [reflex hammer] and deep sensibility [tuning fork (scale)]<br>- Subjective PNP-symptoms [FACT/GOG-Ntx- questionnaire] <br>- Quality of life [EORCT-QLQ-C30-questionnaire]<br>- Performance (watt) at the individual anaerobic threshold [(lactate diagnostic and spiroergometry) by standard incremental bicycle exercise test including ECG3 (electrocardiogram)]<br>- Maximum strength [counter movement jump on force plate]<br>- Physical activity per week (MET = metabolic equivalent) [FFKA-questionnaire]