Exercise- can it help the brain change itself?

Not Applicable

Completed

• Conditions: Stroke; Stroke - Ischaemic

• Registration Number: ACTRN12610001083088
• Lead Sponsor: niversity of South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-12-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Healthy. moderately active right-handed adults for phase I of the trial
Stroke patients, at least 6 months post stroke for phase II

Exclusion Criteria

Epilepsy
Medication to thin the blood or other medication that may alter cortical excitability or response to brain stimulation e.g. antidepressants
Cardiac pacemaker

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
europlasticity as assessed using transcanial magnetic stimulation; participants will have their baseline cortical excitability assessed prior to exercise, then after exercise plasticity will be assessed using theta burst stimulation after both the control and exercise conditions.[Baseline and after exercise and at 30 minutes post exercise]

Secondary Outcome Measures

Name	Time	Method
Blood serum levels of cortisol and brain derived neurotrophic factor[Baseline, post exercise and at 10 and 15 minutes following exercise];Intracortical inhibition meausured using paired pulse TMS at 2 and 3 ms intervals[Before and up to 30 minutes following exercise]