Impact of exercise intervention on neuropathic symptoms in patients with hematologic or oncological malignancies - PNP-pilot-study
- Conditions
- C00-C97G60-G64Malignant neoplasmsPolyneuropathies and other disorders of the peripheral nervous system
- Registration Number
- DRKS00004340
- Lead Sponsor
- Abtl I Medizinische Universitätsklinik Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 11
Haematological/oncological patients with symptoms of PNP regardless their malignant underlying disease or treatment status
Age =18 years
- Performance- Status Karnofsky- Index >60 (see 11.2)
- Negative pregnancy test (urine or serum) for women of reproductive age
- Signed informed consent
- Geographical proximity (< 90 Minutes with transport)
Absolute:
- Instable bone metastases
- Myocardial infarction, Angina pectoris or heart disease (NYHA III-IV) in a time period of six months
- Arterial hypertension, which is not treated adequately (in therapy >180mmHg systolic; >100mmHg diastolic)
- Patients with an increased risk for thrombosis besides underlying disease
Relative (inclusion or continuation after recovery possible):
- Acute infection (=38,0°Celcius and/ or intravenously therapy with antibiotics)
- Thrombocytes < 10x10^9/L
- Leukocytes < 1x10^9/L
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sway path (cm) of centre of pressure [COP]: static postural control
- Secondary Outcome Measures
Name Time Method Sway path (cm) of COP after perturbation: dynamic postural control<br>Body sway (cm): dynamic postural control<br>Nerve conduction velocity (m/s) and amplitude (mm) of stimulus response<br>Value of FACT/GOG-Ntx- questionnaire<br>Value of EORCT-QLQ-C30- questionnaire<br>Performance (Watt) at the IAT<br>h-1-RM (kg)<br>Phase angle (°), FFM (kg, %), FAT (kg, %), BCM (%)<br>MET of FFKA<br>