MOODSTRATIFICATION IMMUNOSTRATAPremature immune ageing to predict the effect of physical training intervention, in mood disorders - IMMUNOSTRATA

niversitätsklinikum Münster0 个研究点目标入组 500 人开始时间: 2020年11月3日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Inclusion criteria for patients with MDD:
•- Depressive episode in the context of a unipolar or bipolar affective disorder
•- HDRS-17 - value >13
•- Age 18-65
•- Preferably patients with antidepressant and/or mood-stabilising medication that does not have a sufficient effect
•- Consent and IC
•Inclusion criteria for healthy controls:
•- No affective disorder in patient history
•- Age 18-65
•- Consent and IC

•Exclusion criteria for MDD patients:
•- Taking beta-blockers
•- Anomalies in the ECG
•- Permanent intake of anti-inflammatory drugs
•- Existing or planned pregnancy or lactation
•- Schizoaffective disorder, schizophrenia
•- Increased risk of suicidal behaviour
•- Chronic uncontrolled systemic or metabolic disease (e.g. diabetes mellitus)
•- Other significant chronic, uncontrolled somatic, organic, neurological diseases that affect mood
•- Current or past (last four weeks) somatic medication that affects immune system or mood (corticosteroids, anti-inflammatory medication, immunosuppressants)
•- inability to complete the study programme
•- Patients who are related to employees or have the same employment relationship
•Exclusion criteria for healthy controls:
•- Permanent use of anti-inflammatory medication
•- Cancer in the last 5 years (except skin cancer or a precursor of cervical cancer)
•- Chronic uncontrolled systemic or metabolic disease (e.g. diabetes mellitus)
•- Other significant chronic, uncontrolled somatic, organic, neurological diseases that affect mood
•- Current or past (last four weeks) somatic medication that affects immune system or mood (corticosteroids, anti-inflammatory medication, immunosuppressants)
•- Existing or planned pregnancy or lactation

发起方

niversitätsklinikum Münster