MOODSTRATIFICATION Immune Signatures for Therapy Stratification in Major Mood Disorders - MOODSTRATIFICATIO

niversitair Medisch Centrum Groningen0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Meets DSM-V criteria for MDD or BD established by MINI Plus
•- Depression severity > 13 on the HDRS-17
•- Age within the range of 18-65 years
•- Already using an antidepressant and/or mood stabilizer without sufficient clinical response

•- Unable to provide informed consent
•- Receiving care in the context of involuntary treatment and hospitalization.
•- Existing or planned pregnancy or lactation
•- Already participating in a other interventional study
•- If at inclusion the planned next step of treatment will be ECT.
•- Cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer).
•- Current manic or mixed episode of bipolar disorders
•- Current severe alcohol or other substance use disorder, needing treatment in a specialized setting
•- Alcohol or other substance dependence in the last year which a patient needed treatment in a specialized setting.
•- Current or recent (last 4 weeks) severe infectious or inflammatory disease
•- Known current uncontrolled systemic disease (e.g. LE, RA)
•- Known major uncontrolled metabolic disorder (e.g. diabetes, hyper- or hypothyroidism, Cushing disease of Addison disease)
•- Known other significant uncontrolled somatic/organic/neurological disorder, such as or diabetes or stroke which may affect mood
•- Current or recent (last 4 weeks) use of somatic medication which may affect mood or the immune system (e.g. corticoids, anti-inflammatory drugs, immune suppressive drugs)

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