Effect of Metformin in control of Diabetes type 1

Phase 3

• Conditions: Diabetes Mellitus Type 1.; Type 1 diabetes mellitus without complications; E10.9

• Registration Number: IRCT20201207049638N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Age from 10 to 20 years old
Duration of Type 1DM more than one year
Insulin dosage more than one unit/ kg /day
Multiple daily insulin injections from at least 1 year ago
HbA1c more than 8% in the past 6 months

Exclusion Criteria

Nephropathy
Proliferative retinopathy
Diabetic ketoacidosis more than twice a year
Recurrent severe hypoglycemia
Current insulin therapy by conventional method (NPH plus Reg)
Renal or hepatic dysfunction

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HbA1C concentration alteration after metformin consumption. Timepoint: Before intervention, 3 months, 6 months, and 9 months after intervention. Method of measurement: Blood test.;Creatinine concentration alteration after metformin consumption. Timepoint: Before intervention, 3 months, 6 months, and 9 months after intervention. Method of measurement: Blood test.