The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Paraoxonase
研究概览
简要总结
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
详细描述
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Cardiac disease
- •Respiratory disease
- •Diabetes mellitus
研究组 & 干预措施
nicotine
use of an e-cigarette filled with liquid with nicotine
干预措施: one time exposure to e-cig with nicotine (Other)
no nicotine
Use of an e-cigarette filled with liquid without nicotine
干预措施: One time exposure to e-cigarette without nicotine (Other)
sham comparator
Use of empty e-cigarette (sham control)
干预措施: one time exposure to empty e-cigarette (Other)
结局指标
主要结局
Paraoxonase
时间窗: less than 1 hour after exposure
plasma oxidative stress
Heart Rate variability
时间窗: 10 minutes after exposure
Heart rate variability is a measure of autonomic tone
次要结局
- muscle sympathetic nerve activity(10 minutes after exposure)
研究者
Holly R Middlekauff
Professor of Medicine
University of California, Los Angeles