E-cigarettes and Blood Vessel Function

Not Applicable

Completed

• Conditions: Nicotine Dependence

• Registration Number: NCT02740595
• Lead Sponsor: University of California, Los Angeles

Brief Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

Detailed Description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Study Timeline

• Study Start: 2015-08
• Study First Submitted: 2016-04-12
• Study First Submitted QC: 2016-04-12
• Study First Posted: 2016-04-15
• Primary Completion: 2022-12-01
• Study Completion: 2022-12-01
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-02
• Last Update Posted: 2023-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

• Healthy

Exclusion Criteria

• Cardiac disease
• Respiratory disease
• Diabetes mellitus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Flow mediated dilatation (FMD)	10 minutes after exposure	FMD is a measure of endothelial function
Paraoxonse	less than 1 hour after exposure	plasma oxidative stress

Trial Locations

Locations (1)

UCaliforniaLA; 🇺🇸 Los Angeles, California, United States