E-cigarettes and Blood Vessel Function
Not Applicable
Completed
- Conditions
- Nicotine Dependence
- Interventions
- Other: one time exposure to e-cig with nicotineOther: one time exposure to e-cig without nicotineOther: one time exposure to empty e-cig
- Registration Number
- NCT02740595
- Lead Sponsor
- University of California, Los Angeles
- Brief Summary
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
- Detailed Description
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 148
Inclusion Criteria
- Healthy
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Exclusion Criteria
- Cardiac disease
- Respiratory disease
- Diabetes mellitus
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Nicotine one time exposure to e-cig with nicotine Use an e-cig filled with liquid with nicotine no nicotine one time exposure to e-cig without nicotine Use an e-cig filled with liquid without nicotine sham comparator one time exposure to empty e-cig Use an empty e-cigarette (sham control)
- Primary Outcome Measures
Name Time Method Paraoxonse less than 1 hour after exposure plasma oxidative stress
Flow mediated dilatation (FMD) 10 minutes after exposure FMD is a measure of endothelial function
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UCaliforniaLA
🇺🇸Los Angeles, California, United States