ECigs, Inflammation and Oxidative Stress
Not Applicable
Completed
- Conditions
- E-cigarettes, Oxidative Stress, Inflammation
- Registration Number
- NCT03823885
- Lead Sponsor
- University of California, Los Angeles
- Brief Summary
Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.
- Detailed Description
Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 148
Inclusion Criteria
- Healthy
Exclusion Criteria
- Cardiac disease Respiratory disease Diabetes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Cellular Reactive Oxygen Species, units = % fluorescence within 4 hours of E-cig use cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells
- Secondary Outcome Measures
Name Time Method CD 14+ Monocyte, units = % of total cells within 4 hours of e-cig use CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye
Trial Locations
- Locations (1)
UCLA
🇺🇸Los Angeles, California, United States
UCLA🇺🇸Los Angeles, California, United States