ECigs, Inflammation and Oxidative Stress

Not Applicable

Completed

• Conditions: E-cigarettes, Oxidative Stress, Inflammation
• Interventions: Other: empty (-cigarette sham control); Other: e-cigarette

• Registration Number: NCT03823885
• Lead Sponsor: University of California, Los Angeles

Brief Summary

Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.

Detailed Description

Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.

Study Timeline

• Study First Submitted: 2019-01-24
• Study First Submitted QC: 2019-01-28
• Study First Posted: 2019-01-31
• Study Start: 2019-02-08
• Primary Completion: 2023-02-08
• Status Verified: 2023-10
• Study Completion: 2023-10-01
• Last Update Submitted: 2023-10-02
• Last Update Posted: 2023-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

• Healthy

Read More

Exclusion Criteria

• Cardiac disease Respiratory disease Diabetes

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
sham	empty (-cigarette sham control)	One time exposure to empty e-cig
E-cig	e-cigarette	One time exposure to e-cig

Primary Outcome Measures

Name	Time	Method
Cellular Reactive Oxygen Species, units = % fluorescence	within 4 hours of E-cig use	cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells

Secondary Outcome Measures

Name	Time	Method
CD 14+ Monocyte, units = % of total cells	within 4 hours of e-cig use	CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye

Trial Locations

Locations (1)

UCLA; 🇺🇸 Los Angeles, California, United States