E-cigarettes, Nicotine Inhaler, and Blood Vessel Function
Not Applicable
Completed
- Conditions
- Nicotine Dependence
- Registration Number
- NCT03072628
- Lead Sponsor
- University of California, Los Angeles
- Brief Summary
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity
- Detailed Description
Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2) e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording for heart rate variability, endothelial function measurement using ultrasound ("FMD") and blood tests for oxidative stress markers.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 148
Inclusion Criteria
- Healthy
Exclusion Criteria
- Cardiac disease
- Respiratory disease
- Diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Flow Mediated dilatation (FMD) 10 minutes after exposure FMD is a measure of endothelial function
Heart rate variability (HRV) 10 minutes after exposure HRV is a measure of cardiac sympathetic tone
- Secondary Outcome Measures
Name Time Method Paraoxonase (PON) ~30 minutes after exposure PON is a measure of oxidative stress
Trial Locations
- Locations (1)
UCaliforniaLA
🇺🇸Los Angeles, California, United States
UCaliforniaLA🇺🇸Los Angeles, California, United States