E-Cigarettes and SNA
Not Applicable
Completed
- Conditions
- Nicotine Dependence
- Interventions
- Other: One time exposure to e-cigarette without nicotineOther: one time exposure to empty e-cigaretteOther: one time exposure to e-cig with nicotine
- Registration Number
- NCT02724241
- Lead Sponsor
- University of California, Los Angeles
- Brief Summary
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
- Detailed Description
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Healthy
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Exclusion Criteria
- Cardiac disease
- Respiratory disease
- Diabetes mellitus
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description no nicotine One time exposure to e-cigarette without nicotine Use of an e-cigarette filled with liquid without nicotine sham comparator one time exposure to empty e-cigarette Use of empty e-cigarette (sham control) nicotine one time exposure to e-cig with nicotine use of an e-cigarette filled with liquid with nicotine
- Primary Outcome Measures
Name Time Method Paraoxonase less than 1 hour after exposure plasma oxidative stress
Heart Rate variability 10 minutes after exposure Heart rate variability is a measure of autonomic tone
- Secondary Outcome Measures
Name Time Method muscle sympathetic nerve activity 10 minutes after exposure Muscle sympathetic nerve activity (MSNA)
Trial Locations
- Locations (1)
UCaliforniaLA
🇺🇸Los Angeles, California, United States