Does Pulmonary Rehabilitation Improve Frailty and Sarcopenia in End Stage Liver Disease?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- End Stage Liver Disease
- Sponsor
- Mayo Clinic
- Enrollment
- 4
- Locations
- 1
- Primary Endpoint
- Change in 6 minute walk test
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program
Detailed Description
Participants will be randomized into two groups. The Pulmonary Rehabilitation group will undergo exercise under a supervised setting for a total duration of 12 weeks. Patients will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session. Exercises will be supervised by physiotherapists or exercise physiologists. Compliance and performance will be monitored by the trainer. They will receive a pedometer for home use. The Home based program group will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Patients will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.
Investigators
Kymberly D. Watt
MD
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •wait listed for liver transplantation with poor 6 MWT
Exclusion Criteria
- •age \< 18 years
- •recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month
- •large esophageal varices without primary prophylaxis
- •active excessive alcohol intake (in the previous 3 months)
- •current overt uncontrolled hepatic encephalopathy
- •hepatopulmonary syndrome with uncontrolled hypoxia
- •portopulmonary hypertension
- •inability to perform exercise
- •marked symptomatic comorbidities (cardiac, pulmonary, renal).
Outcomes
Primary Outcomes
Change in 6 minute walk test
Time Frame: baseline, 3 months
Participants will walk on a straight, flat surface for 6 minutes at a self-determined pace.