Does Pulmonary Rehabilitation Improve Frailty and Sarcopenia in End Stage Liver Disease?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- Mayo Clinic
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Change in 6 minute walk test
研究概览
简要总结
The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program
详细描述
Participants will be randomized into two groups. The Pulmonary Rehabilitation group will undergo exercise under a supervised setting for a total duration of 12 weeks. Patients will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session. Exercises will be supervised by physiotherapists or exercise physiologists. Compliance and performance will be monitored by the trainer. They will receive a pedometer for home use. The Home based program group will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Patients will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •wait listed for liver transplantation with poor 6 MWT
排除标准
- •age < 18 years
- •recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month
- •large esophageal varices without primary prophylaxis
- •active excessive alcohol intake (in the previous 3 months)
- •current overt uncontrolled hepatic encephalopathy
- •hepatopulmonary syndrome with uncontrolled hypoxia
- •portopulmonary hypertension
- •inability to perform exercise
- •marked symptomatic comorbidities (cardiac, pulmonary, renal).
结局指标
主要结局
Change in 6 minute walk test
时间窗: baseline, 3 months
Participants will walk on a straight, flat surface for 6 minutes at a self-determined pace.
次要结局
未报告次要终点