Does Pulmonary Rehabilitation Improve Frailty in Chronic Lung Disease?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Disease, Pulmonary
- Sponsor
- Mayo Clinic
- Enrollment
- 65
- Locations
- 1
- Primary Endpoint
- Number of Participants With Frailty Phenotype at Baseline and 6 Months
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Frailty is a state of health with predisposition to adverse events, morbidity and mortality. Frailty consists of weakness, slowness, low physical activity, exhaustion, and wasting. Frailty is associated with increased hospitalizations and death in lung disease. It is unknown if pulmonary rehabilitation will improve frailty markers.
Detailed Description
Individuals referred to pulmonary rehabilitation will be examined for frailty markers. After completing pulmonary rehabilitation, the same tests will be performed. The effects of pulmonary rehabilitation will be examined.
Investigators
Cassie C. Kennedy, M.D.
Consultant for Critical Care Medicine
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Number of Participants With Frailty Phenotype at Baseline and 6 Months
Time Frame: Baseline, Six months
Frailty phenotype is 3 or more of: slow gait speed, exhaustion, decreased hand grip strength, decreased activity level, or wasting. Grip strength parameters, gait speed, exhaustion per Fried et al. 2001. Wasting is defined as further decrease in fat free mass by body composition measurement using DEXA. Low physical activity would be activity monitor in lower quartile.
Secondary Outcomes
- Change in Strength(after completion of pulmonary rehab, approximately 8 weeks)
- Wasting(after pulmonary rehabilation completion, appoximately 8 weeks)
- Change in Gait Speed(pre and post pulmonary rehab, approximately 8 weeks)
- Improvement in Exhaustion(pre and post pulmonary rehab, approximately 8 weeks)
- Change in Physical Activity Level(pre and post pulmonary rehab, approximately 8 weeks)