Dosage for dexmedetomidine in spinal anaesthesia
Not Applicable
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: 8- Other Procedures
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Ninety patients belonging to ASA physical status I/II, aged 18-60 years of either sex, undergoing elective lower abdominal and lower limb surgeries under planned Subarachnoid Block (SAB).
Exclusion Criteria
Exclusion criteria included patient refusal, contraindication to SAB, hypersensitivity to the drugs being evaluated, Body Mass Index (BMI) more than 40 kg/m2, pregnancy, significant comorbid conditions like uncontrolled hypertension, congestive heart failure, myocardial infarction in the past 6 months, heart block, fixed cardiac output lesions. Cases that needed intraoperative conversion to general anesthesia were also excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary objective was to ascertain a safe IT dexmedetomidine dose for patients undergoing elective lower abdominal and lower limb surgeries and to analyze sensory and motor characteristics with drug combinations being evaluated by comparing duration of the spinal sensory blockade, onset of the sensory and motor blockadeTimepoint: Onset of sensory blockade shall be defined as the time taken from the drug injection to the time to reach T10 level and the offset of sensory block shall be presumed when pin prick sensation at S1 dermatome has returned. Duration of sensory block will be defined as the time interval elapsed between onset of sensory block at T10 to regression of sensory block to S1.
- Secondary Outcome Measures
Name Time Method Secondary outcome measures included level of sedation, comparison of hemodynamic variables and complications, if any.Timepoint: HR, NIBP(systolic , diastolic and mean NIBP) ,SpO2 will be monitored continuously during the course of surgery and data will be recorded at 5 minutes interval for first 20 minutes then at 15 minutes interval till end of first hour, then at 30 minutes interval for next one hour, hourly for further 2 hours, followed by 4 hourly till completion of 24 hrs