The Effect of Stress on DNA Integrity and the Effect of Cognitive Behavioral Therapy on Stress and Infertility in Women

Not Applicable

Completed

• Conditions: Infertility; Stress
• Interventions: Behavioral: Cognitive Behavioral Therapy

• Registration Number: NCT00685282
• Lead Sponsor: Soroka University Medical Center

Brief Summary

The general hypothesis of the research is that stress decreases fertility and that Cognitive Behavioral Therapy will reduce stress and increase fertility. Secondarily, we hypothesize that stress has a detrimental effect on DNA integrity and that stress reduction will reduce DNA damage in the cell.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-05-25
• Study First Submitted QC: 2008-05-25
• Study First Posted: 2008-05-28
• Study Start: 2008-11
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-11
• Last Update Posted: 2013-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• women between the ages of 18-35 without children undergoing IVF treatment

Exclusion Criteria

• undergoing treatment for a DSM-IV axis I psychiatric illness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
COGNITIVE BEHAVIORAL INTERVENTIONS	Cognitive Behavioral Therapy	PSYCHOLOGICAL INTERVENTIONS TO INCLUDE, RELAXATION, STRESS REDUCTION, GUIDED IMAGERY, BREATHING EXERCISES

Primary Outcome Measures

Name	Time	Method
pregnancy	two years

Secondary Outcome Measures

Name	Time	Method
decreased stress	two months
DNA damage/ γH2AX	with in IVF cycle (2 months)

Trial Locations

Locations (1)

IVF Clinic Soroka UMC; 🇮🇱 Beer Sheva, Israel