Comparison of effect of airway nebulisation with lignocaine 2% vs ropivacaine 0.25% on intubation and extubation response in patients undergoing surgery under general anaesthesia, A Randomised double blind clinical trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Hemodynamic parameters ( Heart rate, Mearn arterial Pressure and saturation) at the time of intubation and extubation.
研究概览
简要总结
Both intubation and extubation is associated with hemodynamic changes . To reduce this response we aimed at using local anaesthetics i.e. ropivacaine 0.25% and lignocaine 2% topically .Both the drugs will be given via nebulisation prior to induction. After IEC approval 60 patients of age group 18 to 60 years belonging to ASA 1 and ASA 2 undergoing surgery under general anaesthesia will be enrolled in the double blind study.About 20 min before induction, patients will be given either of the drug via nebulisation. Anaesthesia induction and intubation and extubation will be according to standard protocol. Hemodynamic parameters ie HR, MAP and spo2 will be recorded at various time points. Severity of cough and time to extubation will also be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Stratified block randomization
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 and ASA 2 Patients posted for surgery under general anaesthesia.
排除标准
- •duration of surgery >3 hours.
- •surgery involving the airway.
- •patients with history of respiratory disease or LRI.
- •>3 attempts at laryngoscopy or intubation.
结局指标
主要结局
Hemodynamic parameters ( Heart rate, Mearn arterial Pressure and saturation) at the time of intubation and extubation.
时间窗: MAP, HR, and Spo2 at; | A)Baseline (T1) | B)Upon tracheal intubation (T2) | C)Upon anaesthetic withdrawal (T3) | D)Upon eye opening on verbal commands (T4) | E)Upon tracheal extubation (T5) | F)2 min after extubation (T6)
次要结局
- 1) severity of cough at extubation(2) time to extubation)