Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis
- Conditions
- Chronic Plaque Psoriasis
- Registration Number
- NCT03982394
- Lead Sponsor
- AbbVie
- Brief Summary
This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 2439
- Confirmed diagnosis of moderate to severe chronic plaque-type psoriasis diagnosed by a specialist and presence of moderate to severe psoriasis symptoms according to physician's judgement at time of recruitment.
- Participant starting any approved treatment for psoriasis and physician's decision must be reached prior to recruitment in the study.
- Participant willing to continue with study documentation after cessation of therapy.
- Unwillingness or inability to comply with study requirements.
- Participation in an interventional clinical trial, concurrently or within the last 30 days. Participation in a post-market observational study (PMOS) or Registry is acceptable.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 90 From Month 4 to 3 years PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.
Time to first treatment change From Week 0 (Baseline) to first treatment change Identify time to first treatment change including discontinuation, dose escalation and dosing interval shortening
- Secondary Outcome Measures
Name Time Method Change in Dermatology Quality of Life Index (DLQI) Score From Week 0 to up to 3 years The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. Scores range from 0 (not relevant/not at all) to 3 (very much).
Change in Treatment Satisfaction Questionnaire for Medication (TSQM) score From Week 0 to up to 3 years The Treatment Satisfaction Questionnaire for Medication (TSQM) is a widely used generic measure to assess treatment satisfaction with their medication. This is a 100-point scale with higher scores indicating greater satisfaction with medication and provides scores on four scales - side effects, effectiveness, convenience and global satisfaction.
Time to first treatment change rate At 1 year, 2 year, and 3 year Time to first treatment change including discontinuation, dose escalation and dose interval shortening.
Time to achieve sPGA 0/1 or sPGA 0 Up to 3 years The sPGA is the assessment by the Investigator of the overall disease severity at the time of evaluation. The National Psoriasis Foundation Psoriasis Score version of a static PGA is calculated by averaging the total body erythema, induration, and desquamation scores.
Percentage of participants who achieved PASI 90 or PASI 100 at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval At 4 months and 1 year, 2 years, and 3 years Percentage of participants who achieved PASI 90 or PASI 100 demonstrating a 90 or 100% reduction in PASI at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval.
Change in PASI From Week 0 to up to 3 years PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.
Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval At 4 months to 1 year, 2 years, and 3 years Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval.
Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 75, 90, or 100 Monthly for up to 3 years PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination. Each threshold will be analyzed separately.
Percentage of participants who achieve DLQI 0/1 Monthly for up to 3 years The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. The higher the DLQI score, the more quality of life is impaired.
Percentage of participants who achieved Static Physicians Global Assessment (sPGA) 0/1 or sPGA 0 Monthly for up to 3 years The sPGA is the physician's current assessment of the average thickness, erythema, and scaling of all psoriatic lesions. sPGA scores demonstrate overall psoriatic disease with a lower score indicating less body coverage. The assessment is considered "static" which refers to the patients disease state at the time of the assessments, without comparison to any of the patient's previous disease states, whether at Baseline or at a previous visit.
Percentage of participants who achieved Absolute PASI<=5, <=3 or <=1 Monthly for up to 3 years Used to assess the benefit of psoriasis therapy. Each threshold will be analyzed separately.
Time to achieve PASI 75, 90,or 100 Up to 3 years PASI 75, 90, or 100 defined as at least a 75%/ 90%/ 100% reduction in PASI relative to Week 0 (Baseline). Each threshold will be analyzed separately.
Change in Body Surface Area (BSA) From Week 0 to up to 3 years BSA can be used to quantify the severity of psoriasis. A decrease in BSA affected by psoriasis indicates improvement.
Trial Locations
- Locations (302)
Nagoya City University Hospital /ID# 213363
🇯🇵Nagoya shi, Aichi, Japan
Hospital General Universitario Gregorio Maranon /ID# 231664
🇪🇸Madrid, Spain
Premier Specialist /ID# 218158
🇦🇺Kogarah, New South Wales, Australia
Klinik Donaustadt /ID# 218842
🇦🇹Vienna, Wien, Austria
Praxis Dr. Mihaescu /ID# 213483
🇩🇪Augsburg, Germany
Grossmann, Koblenz, DE /ID# 214245
🇩🇪Koblenz, Germany
Praxis Dr. Korge /ID# 213475
🇩🇪Dueren, Germany
DermaKiel Allergie und Haut Centrum /ID# 213977
🇩🇪Kiel, Schleswig-Holstein, Germany
Azienda Ospedaliera di Perugia /ID# 219033
🇮🇹Perugia, Umbria, Italy
SKIN Clinics /ID# 213082
🇨🇦Brandon, Manitoba, Canada
Hospital General de Mostoles /ID# 225088
🇪🇸Mostoles, Madrid, Spain
Hospital Universitario Principe de Asturias /ID# 225085
🇪🇸Alcala de Henares, Madrid, Spain
Hospital Universitario Severo Ochoa /ID# 225087
🇪🇸Leganes, Madrid, Spain
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 213670
🇩🇪Kiel, Schleswig-Holstein, Germany
Tallaght University Hospital /ID# 212999
🇮🇪Tallaght, Dublin, Ireland
Fremantle Dermatology /ID# 217617
🇦🇺Fremantle, Western Australia, Australia
Hospital Universitario del Sureste /ID# 226561
🇪🇸Arganda del Rey, Madrid, Spain
Hospital Universitario de Getafe /ID# 225086
🇪🇸Getafe, Madrid, Spain
HMS GmbH Zimmer /ID# 225219
🇩🇪Merzig, Saarland, Germany
Buenos Aires Skin /ID# 217657
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
CH Bigorre - Site de la Gespe /ID# 218563
🇫🇷Tarbes CEDEX 9, Hautes-Pyrenees, France
CH William Morey /ID# 225441
🇫🇷Chalon Sur Saone, France
Hautmedizin Bad Soden /ID# 213956
🇩🇪Bad Soden am Taunus, Germany
Timmel/Timm/Vorwerk, Bergen /ID# 214552
🇩🇪Bergen, Germany
Derma Sana /ID# 214544
🇩🇪Karlsruhe, Germany
Veracity Clinical Research /ID# 217618
🇦🇺Woolloongabba, Queensland, Australia
Universitatsklinikum Mannheim /ID# 214569
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Stringa Dermatologia /ID# 218450
🇦🇷Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina
Duplicate_Stratica Medical /ID# 213526
🇨🇦Edmonton, Alberta, Canada
DermEdge Research Inc. /ID# 213525
🇨🇦Mississauga, Ontario, Canada
Emiliano Baccarini Priv Practice /ID# 218581
🇦🇷Lomas de Zamora, Buenos Aires, Argentina
Hospital Universitario Austral /ID# 217540
🇦🇷Pilar, Buenos Aires, Argentina
Stat Research /ID# 217185
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Instituto de Neumonologia y Dermatologia /ID# 217429
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
CEDIC Centro de Investigaciones Clinicas /ID# 217184
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Professional Skin Care /ID# 218514
🇦🇷Buenos Aires, Argentina
Hospital Italiano /ID# 217000
🇦🇷Caba, Argentina
Private Office Cristina Echeverria /ID# 222082
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
EZW HAUT Entzuendungszentrum Wien /ID# 215488
🇦🇹Vienna, Wien, Austria
Psoriahue Med Interdisciplinar /ID# 217182
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Klinikum Wels-Grieskirchen GmbH /ID# 216140
🇦🇹Wels, Oberoesterreich, Austria
Medizinische Universitaet Graz /ID# 217702
🇦🇹Graz, Steiermark, Austria
Klinik Hietzing /ID# 217685
🇦🇹Vienna, Wien, Austria
Haut Trattner Dermatologie /ID# 216138
🇦🇹Hainfeld, Austria
Dr Maksym Breslavets Medicine Professional Corporation /ID# 213338
🇨🇦Whitby, Ontario, Canada
Sociedad de CirugÃa de Bogotá- Hospital de San José /ID# 222683
🇨🇴Bogota, Cundinamarca, Colombia
CHU Dijon /ID# 216247
🇫🇷Dijon, Cote-d Or, France
CH Valence /ID# 225877
🇫🇷Valence, Drome, France
CH du Pays d'AIX /ID# 216440
🇫🇷Aix En Provence Cedex 1, France
Northern Dermatology /ID# 218374
🇦🇺Chermside, Queensland, Australia
Alberta DermaSurgery Centre /ID# 230114
🇨🇦Edmonton, Alberta, Canada
Private Practice - Dr. Kim Papp Clinical Research /ID# 212130
🇨🇦Waterloo, Ontario, Canada
CHU de Rennes - PONTCHAILLOU /ID# 218248
🇫🇷Rennes, Bretagne, France
Hautarzt Dr. Lukas Kraus /ID# 216139
🇦🇹Dornbirn, Vorarlberg, Austria
Medizin am Hauptbahnhof /ID# 218837
🇦🇹Vienna, Wien, Austria
Hôpital d'Instruction des Armées Sainte-Anne /ID# 218888
🇫🇷Toulon CEDEX 9, France
Universitaetsklinikum Erlangen /ID# 213669
🇩🇪Erlangen, Bayern, Germany
Heidlas, Dessau-Rosslau, DE /ID# 217691
🇩🇪Dessau-rosslau, Germany
Universitaetsklinikum Magdeburg /ID# 215080
🇩🇪Magdeburg, Germany
Praxis Dres. Ziegler & Partner /ID# 213647
🇩🇪Stuttgart, Germany
University Hospital Limerick /ID# 216997
🇮🇪Limerick, Ireland
Chukyo Hospital /ID# 213405
🇯🇵Nagoya-shi, Aichi, Japan
Matsuyama Red Cross Hospital /ID# 224745
🇯🇵Matsuyama-shi, Ehime, Japan
Takamatsu Red Cross Hospital /ID# 241120
🇯🇵Takamatsu-shi, Kagawa, Japan
Kyoto University Hospital /ID# 213404
🇯🇵Kyoto-shi, Kyoto, Japan
Skmc /Id# 217873
🇦🇪Abu Dhabi, United Arab Emirates
The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 215476
🇬🇧Kings Lynn, Norfolk, United Kingdom
Tokyo Medical University Hospital /ID# 217125
🇯🇵Shinjuku-ku, Tokyo, Japan
Caja de Compensación Familiar Cafam, Sede Centro de Atención En Salud Cafam Flor /ID# 222660
🇨🇴Bogotá, Cundinamarca, Colombia
CH Georges Renon /ID# 216174
🇫🇷Niort CEDEX, Deux-Sevres, France
Hopitaux Drome Nord /ID# 222586
🇫🇷Romans Sur Isere, Drome, France
Hopital Ambroise Pare /ID# 216439
🇫🇷Boulogne Billancourt, France
Universitaetsmedizin Mainz /ID# 222025
🇩🇪Mainz, Rheinland-Pfalz, Germany
Angela Montgomery Medicine Professional Corporation /ID# 213615
🇨🇦Ottawa, Ontario, Canada
North York Research Inc /ID# 213486
🇨🇦Toronto, Ontario, Canada
Weihe/Stavermann, Berlin, DE /ID# 214550
🇩🇪Berlin, Germany
Hopital de la Cavale Blanche /ID# 216495
🇫🇷Brest, Finistere, France
CHU Grenoble - Hopital Michallon /ID# 218437
🇫🇷La Tronche, Isere, France
C.H. de Bretagne Sud /ID# 216243
🇫🇷Lorient, France
Bell, Andernach, DE /ID# 214545
🇩🇪Andernach, Germany
Praxis T. Schadeck /ID# 213957
🇩🇪Bogen, Germany
Praxis Dres. Kaspari /Schenck /ID# 213649
🇩🇪Hannover, Germany
Hautarztpraxis Langenau /ID# 213651
🇩🇪Langenau, Germany
Karl, Soest, DE /ID# 214547
🇩🇪Soest, Germany
Moeller, Wiesbaden, DE /ID# 213955
🇩🇪Wiesbaden, Germany
Franz, Wolfenbuettel, DE /ID# 215355
🇩🇪Wolfenbuettel, Germany
Szegedi Tudományegyetem /ID# 212958
ðŸ‡ðŸ‡ºSzeged, Hungary
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 218720
🇮🇹Torette, Ancona, Italy
Fondazione PTV Policlinico Tor Vergata /ID# 219031
🇮🇹Rome, Roma, Italy
AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 218546
🇮🇹Napoli, Italy
Azienda Ospedaliera di Padova /ID# 221299
🇮🇹Padova, Italy
Azienda Ospedaliero Universitaria Pisana /ID# 218555
🇮🇹Pisa, Italy
University Hospital Kyoto Prefectural University of Medicine /ID# 213396
🇯🇵Kyoto-shi, Kyoto, Japan
University of the Ryukyus Hospital /ID# 213394
🇯🇵Nakagami-gun, Okinawa, Japan
Jichi Medical University Hospital /ID# 213403
🇯🇵Shimotsuke-shi, Tochigi, Japan
Hasert & Hasert, Berlin, DE /ID# 213641
🇩🇪Berlin, Germany
Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 213113
🇩🇪Heilbad Heiligenstadt, Germany
Duplicate_Praxis Dres. Kloss/Peterburgskiy /ID# 213960
🇩🇪Neuwied, Germany
Zentrum fur Hautgesundheit /ID# 222001
🇩🇪Neuwied, Germany
Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 213444
🇩🇪Witten, Germany
South Infirmary Victoria University Hospital /ID# 213001
🇮🇪Cork, Ireland
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 218718
🇮🇹Rome, Roma, Italy
Teikyo University /ID# 213362
🇯🇵Tokyo, Japan
Praxis Dr. Konstantin Ertner /ID# 213640
🇩🇪Nuremberg, Germany
Praxis Dr. Langhoff /ID# 214253
🇩🇪Schwerin, Germany
Barnikol, Waltershausen, DE /ID# 213219
🇩🇪Waltershausen, Germany
Pfennig, Werdau, DE /ID# 213657
🇩🇪Werdau, Germany
Debreceni Egyetem-Klinikai Kozpont /ID# 212959
ðŸ‡ðŸ‡ºDebrecen, Hajdu-Bihar, Hungary
Presidio Ospedaliero San Salvatore /ID# 218719
🇮🇹L'Aquila, L Aquila, Italy
Istituto Clinico Humanitas /ID# 218560
🇮🇹Rozzano, Milano, Italy
Duplicate_Fujita Health University Hospital /ID# 224742
🇯🇵Toyoake-shi, Aichi, Japan
Imamura General Hospital /ID# 228450
🇯🇵Kagoshima-shi, Kagoshima, Japan
Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 224743
🇯🇵Osaka-shi, Osaka, Japan
Consultorio Privado /Id# 225457
🇲🇽Ciudad de México, Ciudad De Mexico, Mexico
COPERNICUS Podmiot Leczniczy Sp. z o.o. - Szpital sw. Wojciecha Adalberta /ID# 225446
🇵🇱Gdansk, Pomorskie, Poland
Spitalul Clinic Colentina /ID# 224811
🇷🇴Bucuresti, Romania
Kingston Hospital NHS Foundation Trust /ID# 215973
🇬🇧Kingston upon Thames, Surrey, United Kingdom
Kingston Hospital NHS Foundation Trust /ID# 230856
🇬🇧Kingston upon Thames, Surrey, United Kingdom
ASST Spedali civili di Brescia /ID# 218717
🇮🇹Brescia, Italy
Presidio Ospedaliero Gaspare Rodolico /ID# 219032
🇮🇹Catania, Italy
Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 218845
🇮🇹Vicenza, Italy
JR Sapporo Hospital /ID# 213406
🇯🇵Sapporo-shi, Hokkaido, Japan
Labderm S.C. Beata Bergler-Czop, Barbara Sido-Bergler /Id# 225447
🇵🇱Ozarowice, Slaskie, Poland
Tawam Hospital /ID# 217872
🇦🇪Abu Dhabi, United Arab Emirates
Dermatologica Sc /Id# 225449
🇲🇽Tijuana, Baja California, Mexico
Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 218558
🇮🇹Bari, Italy
RM Pharma Specialists S.A de C.V. /ID# 225458
🇲🇽Mexico City, Ciudad De Mexico, Mexico
King Abdulaziz Medical City- National Guard Hospital /ID# 224354
🇸🇦Riyadh, Ar Riyad, Saudi Arabia
Heraa General Hospital /ID# 217214
🇸🇦Makkah, Saudi Arabia
New Medical Center Hospital /ID# 223681
🇦🇪Abu Dhabi, United Arab Emirates
Northampton General Hospital NHS Trust /ID# 249297
🇬🇧Northampton, Northamptonshire, United Kingdom
Elbe Klinikum Buxtehude /ID# 213366
🇩🇪Buxtehude, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 222464
🇩🇪Hamburg, Germany
Kingsway Dermatology & Aesthetics /ID# 217616
🇦🇺Miranda, New South Wales, Australia
Klinik Landstrasse /ID# 217684
🇦🇹Vienna, Wien, Austria
Dr. Brown-Maher PMC INC. /ID# 212136
🇨🇦St. John's, Newfoundland and Labrador, Canada
CCA Medical Research /ID# 214446
🇨🇦Ajax, Ontario, Canada
Dermatrials Research /ID# 213523
🇨🇦Hamilton, Ontario, Canada
Lynde Institute for Dermatology /ID# 212124
🇨🇦Markham, Ontario, Canada
Lima's Excellence in Allergy and Dermatology Research Inc /ID# 231973
🇨🇦Hamilton, Ontario, Canada
LEADER Research /ID# 249701
🇨🇦Hamilton, Ontario, Canada
Hamilton Health Sciences Corporation /ID# 214053
🇨🇦Hamilton, Ontario, Canada
Al-Mohammedi Medicine Professional Corporation /ID# 215408
🇨🇦Mississauga, Ontario, Canada
Dr Melinda Gooderham Medicine Professional Corporation /ID# 212133
🇨🇦Peterborough, Ontario, Canada
Farheen Mussani Medicine Professional Corporation /ID# 213811
🇨🇦Stoney Creek, Ontario, Canada
Clinique D /ID# 212126
🇨🇦Laval, Quebec, Canada
Centre de Recherche St-Louis /ID# 216325
🇨🇦Quebec City, Quebec, Canada
IPS Universitaria /ID# 241832
🇨🇴Medellin, Antioquia, Colombia
Clinisalud del sur /ID# 222685
🇨🇴Medellin, Antioquia, Colombia
Fundacion Hospital Universidad del Norte /ID# 223428
🇨🇴Soledad, Atlantico, Colombia
Fundacion hospitalaria San Vicente de Paul /ID# 222680
🇨🇴MedellÃn, Antioquia, Colombia
Nemocnice Ceske Budejovice a.s. /ID# 216310
🇨🇿Ceske Budejovice, Czechia
Centro Dermatológico Federico Lleras Acosta E.S.E /ID# 222686
🇨🇴Bogotá, Cundinamarca, Colombia
Ciensalud IPS S.A.S /ID# 244608
🇨🇴Barranqulla, Colombia
Fakultni nemocnice Hradec Kralove /ID# 222670
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Olomouc /ID# 215901
🇨🇿Olomouc, Czechia
Duplicate_Fakultni Nemocnice v Motole /ID# 215484
🇨🇿Prague, Czechia
Sanatorium profesora Arenbergera /ID# 215489
🇨🇿Praha, Czechia
Fakultni nemocnice Kralovske Vinohrady /ID# 233184
🇨🇿Praha, Czechia
Hopital Saint Joseph /ID# 223149
🇫🇷Marseille, Bouches-du-Rhone, France
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 217572
🇫🇷Chambery CEDEX, Savoie, France
Centre Hospitalier du Mans /ID# 225729
🇫🇷Le Mans CEDEX 9, Sarthe, France
Ch Chalons En Champagne /Id# 216668
🇫🇷Chalons en Champagne, Marne, France
Ch Auxerre /Id# 216175
🇫🇷Auxerre, Yonne, France
CHU Amiens-Picardie Site Sud /ID# 216170
🇫🇷Amiens CEDEX 1, Somme, France
CH Pontoise - Hopital René Dubos /ID# 216169
🇫🇷Pontoise, Val-d Oise, France
Chu Angers /Id# 216244
🇫🇷Angers, France
CHU de CAEN - Hopital de la Cote de Nacre /ID# 216245
🇫🇷Caen, France
Cabinet Dermatologie et Esthetique /ID# 229132
🇫🇷Cannes, France
CH Annecy Genevois - Site Annecy /ID# 225786
🇫🇷Epagny Metz Tessy, France
Hôpital d'instruction des armées Bégin /ID# 216167
🇫🇷Saint-Mandé cedex, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 216663
🇫🇷St-Priest-en-Jarez, France
CHR Metz-Thionville - Hopital Bel-Air /ID# 225691
🇫🇷Thionville, France
Beldio Research GmbH /ID# 213958
🇩🇪Memmingen, Bayern, Germany
Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 214466
🇩🇪Bramsche, Niedersachsen, Germany
CMS3 Company for Medical Study /ID# 213676
🇩🇪Selters, Rheinland-Pfalz, Germany
Universitaetsklinikum Jena /ID# 214259
🇩🇪Jena, Thueringen, Germany
Hautzentrum Friedrichshain /ID# 213981
🇩🇪Berlin, Germany
Praxis Dr. Sbornik /ID# 213668
🇩🇪Deggendorf, Germany
Mauer, Bad Kreuznach, DE /ID# 224876
🇩🇪Bad Kreuznach, Germany
Praxis Dr. med. Alexander Zich /ID# 245751
🇩🇪Berlin, Germany
Klinikum Rosenhoehe /ID# 215520
🇩🇪Bielefeld, Germany
Hautarztzentrum Tegel /ID# 214849
🇩🇪Berlin, Germany
Praxis fuer Innere Medizin/Rheumatologie /ID# 213653
🇩🇪Blaubeuren, Germany
Barth, Borna, DE /ID# 213643
🇩🇪Borna, Germany
Schwichtenberg, Bremen, DE /ID# 213650
🇩🇪Bremen, Germany
Richter-Huhn, Dresden, DE /ID# 213659
🇩🇪Dresden, Germany
Praxis Herbst /ID# 222024
🇩🇪Darmstadt, Germany
Dres. Cesko u. Körber /ID# 214850
🇩🇪Essen, Germany
Kurzen, Freising, DE /ID# 214567
🇩🇪Freising, Germany
Loth, Gernsbach, DE /ID# 214848
🇩🇪Gernsbach, Germany
Praxis Dr. Lange /ID# 213984
🇩🇪Gera, Germany
Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 213482
🇩🇪Gelsenkirchen, Germany
Gross/Braeu, Giessen, DE /ID# 213367
🇩🇪Giessen, Germany
Brinkmann & Partner, Gladbeck, /ID# 214247
🇩🇪Gladbeck, Germany
Dermatologikum Hamburg /ID# 213978
🇩🇪Hamburg, Germany
Hautarztpraxis Dr. Viehmann /ID# 213675
🇩🇪Gießen, Germany
Goldbek Medical /ID# 214570
🇩🇪Hamburg, Germany
Reinecke, Holzminden, DE /ID# 215081
🇩🇪Holzminden, Germany
Hautarztpraxis Haßberge /ID# 213644
🇩🇪Haßfurt, Germany
Praxis Dres. Bornemann/Reinerth /ID# 213368
🇩🇪Krefeld, Germany
Neubauer, Leipzig, DE /ID# 214548
🇩🇪Leipzig, Germany
Dres. Jacobs & Kollegen /ID# 213652
🇩🇪Kulmbach, Germany
Hagemeier, Loehne, DE /ID# 214845
🇩🇪Loehne, Germany
Noack-Wiemers, Leipzig, DE /ID# 213654
🇩🇪Leipzig, Germany
Dlugosz-Wolf, Luedenscheid, DE /ID# 222000
🇩🇪Luedenscheid, Germany
Bruecher, Magdeburg, DE /ID# 213476
🇩🇪Magdeburg, Germany
Praxis Dr. Raschke /ID# 225213
🇩🇪Magdeburg, Germany
Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 214249
🇩🇪Mainz, Germany
ZENTderma /ID# 213959
🇩🇪Mönchengladbach, Germany
Voelkel, Nuremberg, DE /ID# 213671
🇩🇪Nuremberg, Germany
Kramer/Mortazawi, Remscheid /ID# 213477
🇩🇪Remscheid, Germany
Praxis Dr. Fränken /ID# 214546
🇩🇪Schwelm, Germany
Breitsprecher, Osnabrueck, DE /ID# 213672
🇩🇪Osnabrueck, Germany
Braun, Ueberlingen, DE /ID# 213646
🇩🇪Ueberlingen, Germany
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 212961
ðŸ‡ðŸ‡ºSzombathely, Vas, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 212960
ðŸ‡ðŸ‡ºPecs, Hungary
Azienda Ospedaliera Universitaria Mater Domini- Campus Salvatore Venuta /ID# 218902
🇮🇹Germaneto, Catanzaro, Italy
Università degli Studi di Firenze /ID# 221383
🇮🇹Florence, Firenze, Italy
Ospedale Policlinico San Martino /ID# 218844
🇮🇹Genoa, Genova, Italy
IRCCS Policlinico San Donato /ID# 222002
🇮🇹Milan, Italy
IRCCS Istituto Ortopedico Galeazzi /ID# 218867
🇮🇹Milan, Italy
Azienda Ospedaliera Universitaria Federico II /ID# 218808
🇮🇹Napoli, Italy
Sapienza University of Rome - Polo Pontino /ID# 218557
🇮🇹Terracina, Italy
Fukuoka University Hospital /ID# 213395
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kurume University Hospital /ID# 215034
🇯🇵Kurume-shi, Fukuoka, Japan
Asahikawa Medical University Hospital /ID# 213409
🇯🇵Asahikawa-shi, Hokkaido, Japan
Takagi Dermatological Clinic Branch /ID# 213407
🇯🇵Obihiro-shi, Hokkaido, Japan
Takamatsu Red Cross Hospital /ID# 222875
🇯🇵Takamatsu-shi, Kagawa, Japan
Mie University Hospital /ID# 213387
🇯🇵Tsu-shi, Mie, Japan
Shinshu University Hospital /ID# 213408
🇯🇵Matsumoto-shi, Nagano, Japan
Kansai Medical University Hospital /ID# 213388
🇯🇵Hirakata-shi, Osaka, Japan
Nippon Medical School Hospital /ID# 213391
🇯🇵Bunkyo-ku, Tokyo, Japan
Shizuoka General Hospital /ID# 224744
🇯🇵Shizuoka-shi, Shizuoka, Japan
The Jikei University Hospital /ID# 213393
🇯🇵Minato-ku, Tokyo, Japan
St.Luke's International Hospital /ID# 213392
🇯🇵Chuo-ku, Tokyo, Japan
Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 213389
🇯🇵Shinjuku-ku, Tokyo, Japan
Clinica Los Arcos Iztapalapa /Id# 216982
🇲🇽Ciudad de México, Ciudad De Mexico, Mexico
Grupo Clinico Catei Sociedad Civil /Id# 216978
🇲🇽Guadalajara, Jalisco, Mexico
Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 216979
🇲🇽Mexico City, Mexico
Neki Servicios Medicos Profesionales S D Rl de Cv /Id# 216977
🇲🇽Toluca, Mexico
Hospital Royo Villanova /ID# 231665
🇪🇸Zaragoza, Spain
Laurentius Ziekenhuis /ID# 230503
🇳🇱Roermond, Limburg, Netherlands
Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 225415
🇵🇱Warszawa, Mazowieckie, Poland
Haaglanden Medisch Centrum /ID# 232063
🇳🇱Den Haag, Netherlands
Medisch Centrum Leeuwarden /ID# 215779
🇳🇱Leeuwarden, Netherlands
KSW nr1 w Rzeszowie /ID# 225444
🇵🇱Rzeszow, Podkarpackie, Poland
Spitalul Clinic Colentina /ID# 224810
🇷🇴Bucuresti, Romania
Spitalul Clinic Colentina /ID# 214307
🇷🇴Bucuresti, Romania
Spitalul Clinic Județean de Urgențe "Sfântul Spiridon" /ID# 214335
🇷🇴Jassi, Romania
King Saud University Med City /ID# 219065
🇸🇦Riyadh, Saudi Arabia
Security Forces Hospital /ID# 221073
🇸🇦Riyadh, Saudi Arabia
Hospital de Manacor /ID# 225083
🇪🇸Manacor, Balears, Spain
Hospital ClÃnico Universitario de Santiago-CHUS /ID# 225076
🇪🇸Santiago de Compostela, A Coruna, Spain
Hospital Universitario de Puerto Real /ID# 225103
🇪🇸Puerto Real, Cadiz, Spain
Hospital Universitari Son Espases /ID# 233286
🇪🇸Palma de Mallorca, Illes Balears, Spain
Hospital Santa MarÃa del Rosell /ID# 225100
🇪🇸Cartagena, Murcia, Spain
Hospital Alvaro Cunqueiro CHUVI /ID# 225077
🇪🇸Vigo, Pontevedra, Spain
Hospital Universitario de Bajadoz /ID# 225091
🇪🇸Badajoz, Spain
Hospital Universitario Virgen de las Nieves /ID# 225107
🇪🇸Granada, Spain
Hospital Juan Ramon Jimenez /ID# 225105
🇪🇸Huelva, Spain
Hospital de Leon /ID# 226559
🇪🇸Leon, Spain
Hospital Universitario Lucus Augusti /ID# 233282
🇪🇸Lugo, Spain
Hospital San Telmo /ID# 233283
🇪🇸Palencia, Spain
Hospital Clinico Universitario Lozano Blesa /ID# 231663
🇪🇸Zaragoza, Spain
Hospital Universitario Virgen de Valme /ID# 225104
🇪🇸Sevilla, Spain
Hospital Universitario 12 de Octubre /ID# 238474
🇪🇸Madrid, Spain
Hospital Universitario de Salamanca /ID# 225078
🇪🇸Salamanca, Spain
Hospital Universitario Ramon y Cajal /ID# 225093
🇪🇸Madrid, Spain
Hospital Virgen de la Concha /ID# 233285
🇪🇸Zamora, Spain
Hospital Universitario Miguel Servet /ID# 225080
🇪🇸Zaragoza, Spain
Waldhotel Health & Medical Excellence /Id# 212743
🇨ðŸ‡Obburgen, Nidwalden, Switzerland
Haut. Venen. Allergie. Zentrum Brunnehof /ID# 212742
🇨ðŸ‡Uster, Zuerich, Switzerland
University Hospital Zurich /ID# 216539
🇨ðŸ‡Zurich, Zuerich, Switzerland
Inselspital, Universitaetsspital Bern /ID# 212741
🇨ðŸ‡Bern, Switzerland
Mediclinic Khalifa Branch /ID# 217871
🇦🇪Abu Dhabi, United Arab Emirates
Mediclinic Welcare Hospital /ID# 223683
🇦🇪Dubai, United Arab Emirates
Imperial College London - St Mary's Hospital /ID# 215978
🇬🇧London, London, City Of, United Kingdom
Addenbrooke's Hospital /ID# 215972
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Frimley Health NHS Foundation Trust /ID# 215976
🇬🇧Camberley, Surrey, United Kingdom
West Suffolk Hospital /ID# 249283
🇬🇧Bury St Edmunds, Suffolk, United Kingdom
The Dudley Group NHS Foundation Trust /ID# 215839
🇬🇧Dudley, United Kingdom
Ulster Hospital - South Eastern Health & Social Care Trust /ID# 215477
🇬🇧Belfast, United Kingdom
NHS Lothian /ID# 249287
🇬🇧Edinburgh, United Kingdom
Northern Care Alliance NHS Group /ID# 218589
🇬🇧Manchester, United Kingdom
York and Scarborough Teaching Hospitals NHS Foundation Trust /ID# 227940
🇬🇧York, United Kingdom
Sandwell and West Birmingham Hospitals NHS Trust /ID# 249294
🇬🇧Lyndon, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 215479
🇬🇧Newcastle upon Tyne, United Kingdom
Winnipeg Clinic /ID# 212134
🇨🇦Winnipeg, Manitoba, Canada
Skin Health Institute Inc /ID# 217619
🇦🇺Carlton, Victoria, Australia
Beacon Dermatology Inc /ID# 213524
🇨🇦Calgary, Alberta, Canada
University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 213507
🇨🇦Vancouver, British Columbia, Canada
Dr. Irina Turchin PC Inc. /ID# 212128
🇨🇦Fredericton, New Brunswick, Canada
Karma Clinical Trials /ID# 213522
🇨🇦St. John's, Newfoundland and Labrador, Canada
NewLab Clinical Research Inc. /ID# 213521
🇨🇦St. John's, Newfoundland and Labrador, Canada
SimcoDerm Medical and Surgical Dermatology Center /ID# 213081
🇨🇦Barrie, Ontario, Canada
Healthy Medical Center S.A.S /ID# 231909
🇨🇴Zipaquirá, Cundinamarca, Colombia
Centro Dermatologico Del Country S de Rl de Cv /Id# 225460
🇲🇽Guadalajara, Jalisco, Mexico
Radboud Universitair Medisch Centrum /ID# 213592
🇳🇱Nijmegen, Gelderland, Netherlands
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 225084
🇪🇸Majadahonda, Madrid, Spain
Universitätsspital Basel /ID# 212744
🇨ðŸ‡Basel Town, Basel-Stadt, Switzerland
Cwm Taf Morgannwg University Health Board /ID# 215974
🇬🇧Bridgend, Wales, United Kingdom