MedPath

Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis

Active, not recruiting
Conditions
Chronic Plaque Psoriasis
Registration Number
NCT03982394
Lead Sponsor
AbbVie
Brief Summary

This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.

Detailed Description

Not available

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
2439
Inclusion Criteria
  • Confirmed diagnosis of moderate to severe chronic plaque-type psoriasis diagnosed by a specialist and presence of moderate to severe psoriasis symptoms according to physician's judgement at time of recruitment.
  • Participant starting any approved treatment for psoriasis and physician's decision must be reached prior to recruitment in the study.
  • Participant willing to continue with study documentation after cessation of therapy.
Read More
Exclusion Criteria
  • Unwillingness or inability to comply with study requirements.
  • Participation in an interventional clinical trial, concurrently or within the last 30 days. Participation in a post-market observational study (PMOS) or Registry is acceptable.
Read More

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 90From Month 4 to 3 years

PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.

Time to first treatment changeFrom Week 0 (Baseline) to first treatment change

Identify time to first treatment change including discontinuation, dose escalation and dosing interval shortening

Secondary Outcome Measures
NameTimeMethod
Change in Dermatology Quality of Life Index (DLQI) ScoreFrom Week 0 to up to 3 years

The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. Scores range from 0 (not relevant/not at all) to 3 (very much).

Change in Treatment Satisfaction Questionnaire for Medication (TSQM) scoreFrom Week 0 to up to 3 years

The Treatment Satisfaction Questionnaire for Medication (TSQM) is a widely used generic measure to assess treatment satisfaction with their medication. This is a 100-point scale with higher scores indicating greater satisfaction with medication and provides scores on four scales - side effects, effectiveness, convenience and global satisfaction.

Time to first treatment change rateAt 1 year, 2 year, and 3 year

Time to first treatment change including discontinuation, dose escalation and dose interval shortening.

Time to achieve sPGA 0/1 or sPGA 0Up to 3 years

The sPGA is the assessment by the Investigator of the overall disease severity at the time of evaluation. The National Psoriasis Foundation Psoriasis Score version of a static PGA is calculated by averaging the total body erythema, induration, and desquamation scores.

Percentage of participants who achieved PASI 90 or PASI 100 at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing intervalAt 4 months and 1 year, 2 years, and 3 years

Percentage of participants who achieved PASI 90 or PASI 100 demonstrating a 90 or 100% reduction in PASI at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval.

Change in PASIFrom Week 0 to up to 3 years

PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.

Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose intervalAt 4 months to 1 year, 2 years, and 3 years

Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval.

Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 75, 90, or 100Monthly for up to 3 years

PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination. Each threshold will be analyzed separately.

Percentage of participants who achieve DLQI 0/1Monthly for up to 3 years

The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. The higher the DLQI score, the more quality of life is impaired.

Percentage of participants who achieved Static Physicians Global Assessment (sPGA) 0/1 or sPGA 0Monthly for up to 3 years

The sPGA is the physician's current assessment of the average thickness, erythema, and scaling of all psoriatic lesions. sPGA scores demonstrate overall psoriatic disease with a lower score indicating less body coverage. The assessment is considered "static" which refers to the patients disease state at the time of the assessments, without comparison to any of the patient's previous disease states, whether at Baseline or at a previous visit.

Percentage of participants who achieved Absolute PASI<=5, <=3 or <=1Monthly for up to 3 years

Used to assess the benefit of psoriasis therapy. Each threshold will be analyzed separately.

Time to achieve PASI 75, 90,or 100Up to 3 years

PASI 75, 90, or 100 defined as at least a 75%/ 90%/ 100% reduction in PASI relative to Week 0 (Baseline). Each threshold will be analyzed separately.

Change in Body Surface Area (BSA)From Week 0 to up to 3 years

BSA can be used to quantify the severity of psoriasis. A decrease in BSA affected by psoriasis indicates improvement.

Trial Locations

Locations (302)

Nagoya City University Hospital /ID# 213363

🇯🇵

Nagoya shi, Aichi, Japan

Hospital General Universitario Gregorio Maranon /ID# 231664

🇪🇸

Madrid, Spain

Premier Specialist /ID# 218158

🇦🇺

Kogarah, New South Wales, Australia

Klinik Donaustadt /ID# 218842

🇦🇹

Vienna, Wien, Austria

Praxis Dr. Mihaescu /ID# 213483

🇩🇪

Augsburg, Germany

Grossmann, Koblenz, DE /ID# 214245

🇩🇪

Koblenz, Germany

Praxis Dr. Korge /ID# 213475

🇩🇪

Dueren, Germany

DermaKiel Allergie und Haut Centrum /ID# 213977

🇩🇪

Kiel, Schleswig-Holstein, Germany

Azienda Ospedaliera di Perugia /ID# 219033

🇮🇹

Perugia, Umbria, Italy

SKIN Clinics /ID# 213082

🇨🇦

Brandon, Manitoba, Canada

Hospital General de Mostoles /ID# 225088

🇪🇸

Mostoles, Madrid, Spain

Hospital Universitario Principe de Asturias /ID# 225085

🇪🇸

Alcala de Henares, Madrid, Spain

Hospital Universitario Severo Ochoa /ID# 225087

🇪🇸

Leganes, Madrid, Spain

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 213670

🇩🇪

Kiel, Schleswig-Holstein, Germany

Tallaght University Hospital /ID# 212999

🇮🇪

Tallaght, Dublin, Ireland

Fremantle Dermatology /ID# 217617

🇦🇺

Fremantle, Western Australia, Australia

Hospital Universitario del Sureste /ID# 226561

🇪🇸

Arganda del Rey, Madrid, Spain

Hospital Universitario de Getafe /ID# 225086

🇪🇸

Getafe, Madrid, Spain

HMS GmbH Zimmer /ID# 225219

🇩🇪

Merzig, Saarland, Germany

Buenos Aires Skin /ID# 217657

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

CH Bigorre - Site de la Gespe /ID# 218563

🇫🇷

Tarbes CEDEX 9, Hautes-Pyrenees, France

CH William Morey /ID# 225441

🇫🇷

Chalon Sur Saone, France

Hautmedizin Bad Soden /ID# 213956

🇩🇪

Bad Soden am Taunus, Germany

Timmel/Timm/Vorwerk, Bergen /ID# 214552

🇩🇪

Bergen, Germany

Derma Sana /ID# 214544

🇩🇪

Karlsruhe, Germany

Veracity Clinical Research /ID# 217618

🇦🇺

Woolloongabba, Queensland, Australia

Universitatsklinikum Mannheim /ID# 214569

🇩🇪

Mannheim, Baden-Wuerttemberg, Germany

Stringa Dermatologia /ID# 218450

🇦🇷

Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina

Duplicate_Stratica Medical /ID# 213526

🇨🇦

Edmonton, Alberta, Canada

DermEdge Research Inc. /ID# 213525

🇨🇦

Mississauga, Ontario, Canada

Emiliano Baccarini Priv Practice /ID# 218581

🇦🇷

Lomas de Zamora, Buenos Aires, Argentina

Hospital Universitario Austral /ID# 217540

🇦🇷

Pilar, Buenos Aires, Argentina

Stat Research /ID# 217185

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

Instituto de Neumonologia y Dermatologia /ID# 217429

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

CEDIC Centro de Investigaciones Clinicas /ID# 217184

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

Professional Skin Care /ID# 218514

🇦🇷

Buenos Aires, Argentina

Hospital Italiano /ID# 217000

🇦🇷

Caba, Argentina

Private Office Cristina Echeverria /ID# 222082

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

EZW HAUT Entzuendungszentrum Wien /ID# 215488

🇦🇹

Vienna, Wien, Austria

Psoriahue Med Interdisciplinar /ID# 217182

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

Klinikum Wels-Grieskirchen GmbH /ID# 216140

🇦🇹

Wels, Oberoesterreich, Austria

Medizinische Universitaet Graz /ID# 217702

🇦🇹

Graz, Steiermark, Austria

Klinik Hietzing /ID# 217685

🇦🇹

Vienna, Wien, Austria

Haut Trattner Dermatologie /ID# 216138

🇦🇹

Hainfeld, Austria

Dr Maksym Breslavets Medicine Professional Corporation /ID# 213338

🇨🇦

Whitby, Ontario, Canada

Sociedad de Cirugía de Bogotá- Hospital de San José /ID# 222683

🇨🇴

Bogota, Cundinamarca, Colombia

CHU Dijon /ID# 216247

🇫🇷

Dijon, Cote-d Or, France

CH Valence /ID# 225877

🇫🇷

Valence, Drome, France

CH du Pays d'AIX /ID# 216440

🇫🇷

Aix En Provence Cedex 1, France

Northern Dermatology /ID# 218374

🇦🇺

Chermside, Queensland, Australia

Alberta DermaSurgery Centre /ID# 230114

🇨🇦

Edmonton, Alberta, Canada

Private Practice - Dr. Kim Papp Clinical Research /ID# 212130

🇨🇦

Waterloo, Ontario, Canada

CHU de Rennes - PONTCHAILLOU /ID# 218248

🇫🇷

Rennes, Bretagne, France

Hautarzt Dr. Lukas Kraus /ID# 216139

🇦🇹

Dornbirn, Vorarlberg, Austria

Medizin am Hauptbahnhof /ID# 218837

🇦🇹

Vienna, Wien, Austria

Hôpital d'Instruction des Armées Sainte-Anne /ID# 218888

🇫🇷

Toulon CEDEX 9, France

Universitaetsklinikum Erlangen /ID# 213669

🇩🇪

Erlangen, Bayern, Germany

Heidlas, Dessau-Rosslau, DE /ID# 217691

🇩🇪

Dessau-rosslau, Germany

Universitaetsklinikum Magdeburg /ID# 215080

🇩🇪

Magdeburg, Germany

Praxis Dres. Ziegler & Partner /ID# 213647

🇩🇪

Stuttgart, Germany

University Hospital Limerick /ID# 216997

🇮🇪

Limerick, Ireland

Chukyo Hospital /ID# 213405

🇯🇵

Nagoya-shi, Aichi, Japan

Matsuyama Red Cross Hospital /ID# 224745

🇯🇵

Matsuyama-shi, Ehime, Japan

Takamatsu Red Cross Hospital /ID# 241120

🇯🇵

Takamatsu-shi, Kagawa, Japan

Kyoto University Hospital /ID# 213404

🇯🇵

Kyoto-shi, Kyoto, Japan

Skmc /Id# 217873

🇦🇪

Abu Dhabi, United Arab Emirates

The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 215476

🇬🇧

Kings Lynn, Norfolk, United Kingdom

Tokyo Medical University Hospital /ID# 217125

🇯🇵

Shinjuku-ku, Tokyo, Japan

Caja de Compensación Familiar Cafam, Sede Centro de Atención En Salud Cafam Flor /ID# 222660

🇨🇴

Bogotá, Cundinamarca, Colombia

CH Georges Renon /ID# 216174

🇫🇷

Niort CEDEX, Deux-Sevres, France

Hopitaux Drome Nord /ID# 222586

🇫🇷

Romans Sur Isere, Drome, France

Hopital Ambroise Pare /ID# 216439

🇫🇷

Boulogne Billancourt, France

Universitaetsmedizin Mainz /ID# 222025

🇩🇪

Mainz, Rheinland-Pfalz, Germany

Angela Montgomery Medicine Professional Corporation /ID# 213615

🇨🇦

Ottawa, Ontario, Canada

North York Research Inc /ID# 213486

🇨🇦

Toronto, Ontario, Canada

Weihe/Stavermann, Berlin, DE /ID# 214550

🇩🇪

Berlin, Germany

Hopital de la Cavale Blanche /ID# 216495

🇫🇷

Brest, Finistere, France

CHU Grenoble - Hopital Michallon /ID# 218437

🇫🇷

La Tronche, Isere, France

C.H. de Bretagne Sud /ID# 216243

🇫🇷

Lorient, France

Bell, Andernach, DE /ID# 214545

🇩🇪

Andernach, Germany

Praxis T. Schadeck /ID# 213957

🇩🇪

Bogen, Germany

Praxis Dres. Kaspari /Schenck /ID# 213649

🇩🇪

Hannover, Germany

Hautarztpraxis Langenau /ID# 213651

🇩🇪

Langenau, Germany

Karl, Soest, DE /ID# 214547

🇩🇪

Soest, Germany

Moeller, Wiesbaden, DE /ID# 213955

🇩🇪

Wiesbaden, Germany

Franz, Wolfenbuettel, DE /ID# 215355

🇩🇪

Wolfenbuettel, Germany

Szegedi Tudományegyetem /ID# 212958

🇭🇺

Szeged, Hungary

Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 218720

🇮🇹

Torette, Ancona, Italy

Fondazione PTV Policlinico Tor Vergata /ID# 219031

🇮🇹

Rome, Roma, Italy

AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 218546

🇮🇹

Napoli, Italy

Azienda Ospedaliera di Padova /ID# 221299

🇮🇹

Padova, Italy

Azienda Ospedaliero Universitaria Pisana /ID# 218555

🇮🇹

Pisa, Italy

University Hospital Kyoto Prefectural University of Medicine /ID# 213396

🇯🇵

Kyoto-shi, Kyoto, Japan

University of the Ryukyus Hospital /ID# 213394

🇯🇵

Nakagami-gun, Okinawa, Japan

Jichi Medical University Hospital /ID# 213403

🇯🇵

Shimotsuke-shi, Tochigi, Japan

Hasert & Hasert, Berlin, DE /ID# 213641

🇩🇪

Berlin, Germany

Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 213113

🇩🇪

Heilbad Heiligenstadt, Germany

Duplicate_Praxis Dres. Kloss/Peterburgskiy /ID# 213960

🇩🇪

Neuwied, Germany

Zentrum fur Hautgesundheit /ID# 222001

🇩🇪

Neuwied, Germany

Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 213444

🇩🇪

Witten, Germany

South Infirmary Victoria University Hospital /ID# 213001

🇮🇪

Cork, Ireland

Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 218718

🇮🇹

Rome, Roma, Italy

Teikyo University /ID# 213362

🇯🇵

Tokyo, Japan

Praxis Dr. Konstantin Ertner /ID# 213640

🇩🇪

Nuremberg, Germany

Praxis Dr. Langhoff /ID# 214253

🇩🇪

Schwerin, Germany

Barnikol, Waltershausen, DE /ID# 213219

🇩🇪

Waltershausen, Germany

Pfennig, Werdau, DE /ID# 213657

🇩🇪

Werdau, Germany

Debreceni Egyetem-Klinikai Kozpont /ID# 212959

🇭🇺

Debrecen, Hajdu-Bihar, Hungary

Presidio Ospedaliero San Salvatore /ID# 218719

🇮🇹

L'Aquila, L Aquila, Italy

Istituto Clinico Humanitas /ID# 218560

🇮🇹

Rozzano, Milano, Italy

Duplicate_Fujita Health University Hospital /ID# 224742

🇯🇵

Toyoake-shi, Aichi, Japan

Imamura General Hospital /ID# 228450

🇯🇵

Kagoshima-shi, Kagoshima, Japan

Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 224743

🇯🇵

Osaka-shi, Osaka, Japan

Consultorio Privado /Id# 225457

🇲🇽

Ciudad de México, Ciudad De Mexico, Mexico

COPERNICUS Podmiot Leczniczy Sp. z o.o. - Szpital sw. Wojciecha Adalberta /ID# 225446

🇵🇱

Gdansk, Pomorskie, Poland

Spitalul Clinic Colentina /ID# 224811

🇷🇴

Bucuresti, Romania

Kingston Hospital NHS Foundation Trust /ID# 215973

🇬🇧

Kingston upon Thames, Surrey, United Kingdom

Kingston Hospital NHS Foundation Trust /ID# 230856

🇬🇧

Kingston upon Thames, Surrey, United Kingdom

ASST Spedali civili di Brescia /ID# 218717

🇮🇹

Brescia, Italy

Presidio Ospedaliero Gaspare Rodolico /ID# 219032

🇮🇹

Catania, Italy

Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 218845

🇮🇹

Vicenza, Italy

JR Sapporo Hospital /ID# 213406

🇯🇵

Sapporo-shi, Hokkaido, Japan

Labderm S.C. Beata Bergler-Czop, Barbara Sido-Bergler /Id# 225447

🇵🇱

Ozarowice, Slaskie, Poland

Tawam Hospital /ID# 217872

🇦🇪

Abu Dhabi, United Arab Emirates

Dermatologica Sc /Id# 225449

🇲🇽

Tijuana, Baja California, Mexico

Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 218558

🇮🇹

Bari, Italy

RM Pharma Specialists S.A de C.V. /ID# 225458

🇲🇽

Mexico City, Ciudad De Mexico, Mexico

King Abdulaziz Medical City- National Guard Hospital /ID# 224354

🇸🇦

Riyadh, Ar Riyad, Saudi Arabia

Heraa General Hospital /ID# 217214

🇸🇦

Makkah, Saudi Arabia

New Medical Center Hospital /ID# 223681

🇦🇪

Abu Dhabi, United Arab Emirates

Northampton General Hospital NHS Trust /ID# 249297

🇬🇧

Northampton, Northamptonshire, United Kingdom

Elbe Klinikum Buxtehude /ID# 213366

🇩🇪

Buxtehude, Germany

Universitaetsklinikum Hamburg-Eppendorf /ID# 222464

🇩🇪

Hamburg, Germany

Kingsway Dermatology & Aesthetics /ID# 217616

🇦🇺

Miranda, New South Wales, Australia

Klinik Landstrasse /ID# 217684

🇦🇹

Vienna, Wien, Austria

Dr. Brown-Maher PMC INC. /ID# 212136

🇨🇦

St. John's, Newfoundland and Labrador, Canada

CCA Medical Research /ID# 214446

🇨🇦

Ajax, Ontario, Canada

Dermatrials Research /ID# 213523

🇨🇦

Hamilton, Ontario, Canada

Lynde Institute for Dermatology /ID# 212124

🇨🇦

Markham, Ontario, Canada

Lima's Excellence in Allergy and Dermatology Research Inc /ID# 231973

🇨🇦

Hamilton, Ontario, Canada

LEADER Research /ID# 249701

🇨🇦

Hamilton, Ontario, Canada

Hamilton Health Sciences Corporation /ID# 214053

🇨🇦

Hamilton, Ontario, Canada

Al-Mohammedi Medicine Professional Corporation /ID# 215408

🇨🇦

Mississauga, Ontario, Canada

Dr Melinda Gooderham Medicine Professional Corporation /ID# 212133

🇨🇦

Peterborough, Ontario, Canada

Farheen Mussani Medicine Professional Corporation /ID# 213811

🇨🇦

Stoney Creek, Ontario, Canada

Clinique D /ID# 212126

🇨🇦

Laval, Quebec, Canada

Centre de Recherche St-Louis /ID# 216325

🇨🇦

Quebec City, Quebec, Canada

IPS Universitaria /ID# 241832

🇨🇴

Medellin, Antioquia, Colombia

Clinisalud del sur /ID# 222685

🇨🇴

Medellin, Antioquia, Colombia

Fundacion Hospital Universidad del Norte /ID# 223428

🇨🇴

Soledad, Atlantico, Colombia

Fundacion hospitalaria San Vicente de Paul /ID# 222680

🇨🇴

Medellín, Antioquia, Colombia

Nemocnice Ceske Budejovice a.s. /ID# 216310

🇨🇿

Ceske Budejovice, Czechia

Centro Dermatológico Federico Lleras Acosta E.S.E /ID# 222686

🇨🇴

Bogotá, Cundinamarca, Colombia

Ciensalud IPS S.A.S /ID# 244608

🇨🇴

Barranqulla, Colombia

Fakultni nemocnice Hradec Kralove /ID# 222670

🇨🇿

Hradec Kralove, Czechia

Fakultni nemocnice Olomouc /ID# 215901

🇨🇿

Olomouc, Czechia

Duplicate_Fakultni Nemocnice v Motole /ID# 215484

🇨🇿

Prague, Czechia

Sanatorium profesora Arenbergera /ID# 215489

🇨🇿

Praha, Czechia

Fakultni nemocnice Kralovske Vinohrady /ID# 233184

🇨🇿

Praha, Czechia

Hopital Saint Joseph /ID# 223149

🇫🇷

Marseille, Bouches-du-Rhone, France

Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 217572

🇫🇷

Chambery CEDEX, Savoie, France

Centre Hospitalier du Mans /ID# 225729

🇫🇷

Le Mans CEDEX 9, Sarthe, France

Ch Chalons En Champagne /Id# 216668

🇫🇷

Chalons en Champagne, Marne, France

Ch Auxerre /Id# 216175

🇫🇷

Auxerre, Yonne, France

CHU Amiens-Picardie Site Sud /ID# 216170

🇫🇷

Amiens CEDEX 1, Somme, France

CH Pontoise - Hopital René Dubos /ID# 216169

🇫🇷

Pontoise, Val-d Oise, France

Chu Angers /Id# 216244

🇫🇷

Angers, France

CHU de CAEN - Hopital de la Cote de Nacre /ID# 216245

🇫🇷

Caen, France

Cabinet Dermatologie et Esthetique /ID# 229132

🇫🇷

Cannes, France

CH Annecy Genevois - Site Annecy /ID# 225786

🇫🇷

Epagny Metz Tessy, France

Hôpital d'instruction des armées Bégin /ID# 216167

🇫🇷

Saint-Mandé cedex, France

Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 216663

🇫🇷

St-Priest-en-Jarez, France

CHR Metz-Thionville - Hopital Bel-Air /ID# 225691

🇫🇷

Thionville, France

Beldio Research GmbH /ID# 213958

🇩🇪

Memmingen, Bayern, Germany

Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 214466

🇩🇪

Bramsche, Niedersachsen, Germany

CMS3 Company for Medical Study /ID# 213676

🇩🇪

Selters, Rheinland-Pfalz, Germany

Universitaetsklinikum Jena /ID# 214259

🇩🇪

Jena, Thueringen, Germany

Hautzentrum Friedrichshain /ID# 213981

🇩🇪

Berlin, Germany

Praxis Dr. Sbornik /ID# 213668

🇩🇪

Deggendorf, Germany

Mauer, Bad Kreuznach, DE /ID# 224876

🇩🇪

Bad Kreuznach, Germany

Praxis Dr. med. Alexander Zich /ID# 245751

🇩🇪

Berlin, Germany

Klinikum Rosenhoehe /ID# 215520

🇩🇪

Bielefeld, Germany

Hautarztzentrum Tegel /ID# 214849

🇩🇪

Berlin, Germany

Praxis fuer Innere Medizin/Rheumatologie /ID# 213653

🇩🇪

Blaubeuren, Germany

Barth, Borna, DE /ID# 213643

🇩🇪

Borna, Germany

Schwichtenberg, Bremen, DE /ID# 213650

🇩🇪

Bremen, Germany

Richter-Huhn, Dresden, DE /ID# 213659

🇩🇪

Dresden, Germany

Praxis Herbst /ID# 222024

🇩🇪

Darmstadt, Germany

Dres. Cesko u. Körber /ID# 214850

🇩🇪

Essen, Germany

Kurzen, Freising, DE /ID# 214567

🇩🇪

Freising, Germany

Loth, Gernsbach, DE /ID# 214848

🇩🇪

Gernsbach, Germany

Praxis Dr. Lange /ID# 213984

🇩🇪

Gera, Germany

Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 213482

🇩🇪

Gelsenkirchen, Germany

Gross/Braeu, Giessen, DE /ID# 213367

🇩🇪

Giessen, Germany

Brinkmann & Partner, Gladbeck, /ID# 214247

🇩🇪

Gladbeck, Germany

Dermatologikum Hamburg /ID# 213978

🇩🇪

Hamburg, Germany

Hautarztpraxis Dr. Viehmann /ID# 213675

🇩🇪

Gießen, Germany

Goldbek Medical /ID# 214570

🇩🇪

Hamburg, Germany

Reinecke, Holzminden, DE /ID# 215081

🇩🇪

Holzminden, Germany

Hautarztpraxis Haßberge /ID# 213644

🇩🇪

Haßfurt, Germany

Praxis Dres. Bornemann/Reinerth /ID# 213368

🇩🇪

Krefeld, Germany

Neubauer, Leipzig, DE /ID# 214548

🇩🇪

Leipzig, Germany

Dres. Jacobs & Kollegen /ID# 213652

🇩🇪

Kulmbach, Germany

Hagemeier, Loehne, DE /ID# 214845

🇩🇪

Loehne, Germany

Noack-Wiemers, Leipzig, DE /ID# 213654

🇩🇪

Leipzig, Germany

Dlugosz-Wolf, Luedenscheid, DE /ID# 222000

🇩🇪

Luedenscheid, Germany

Bruecher, Magdeburg, DE /ID# 213476

🇩🇪

Magdeburg, Germany

Praxis Dr. Raschke /ID# 225213

🇩🇪

Magdeburg, Germany

Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 214249

🇩🇪

Mainz, Germany

ZENTderma /ID# 213959

🇩🇪

Mönchengladbach, Germany

Voelkel, Nuremberg, DE /ID# 213671

🇩🇪

Nuremberg, Germany

Kramer/Mortazawi, Remscheid /ID# 213477

🇩🇪

Remscheid, Germany

Praxis Dr. Fränken /ID# 214546

🇩🇪

Schwelm, Germany

Breitsprecher, Osnabrueck, DE /ID# 213672

🇩🇪

Osnabrueck, Germany

Braun, Ueberlingen, DE /ID# 213646

🇩🇪

Ueberlingen, Germany

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 212961

🇭🇺

Szombathely, Vas, Hungary

Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 212960

🇭🇺

Pecs, Hungary

Azienda Ospedaliera Universitaria Mater Domini- Campus Salvatore Venuta /ID# 218902

🇮🇹

Germaneto, Catanzaro, Italy

Università degli Studi di Firenze /ID# 221383

🇮🇹

Florence, Firenze, Italy

Ospedale Policlinico San Martino /ID# 218844

🇮🇹

Genoa, Genova, Italy

IRCCS Policlinico San Donato /ID# 222002

🇮🇹

Milan, Italy

IRCCS Istituto Ortopedico Galeazzi /ID# 218867

🇮🇹

Milan, Italy

Azienda Ospedaliera Universitaria Federico II /ID# 218808

🇮🇹

Napoli, Italy

Sapienza University of Rome - Polo Pontino /ID# 218557

🇮🇹

Terracina, Italy

Fukuoka University Hospital /ID# 213395

🇯🇵

Fukuoka-shi, Fukuoka, Japan

Kurume University Hospital /ID# 215034

🇯🇵

Kurume-shi, Fukuoka, Japan

Asahikawa Medical University Hospital /ID# 213409

🇯🇵

Asahikawa-shi, Hokkaido, Japan

Takagi Dermatological Clinic Branch /ID# 213407

🇯🇵

Obihiro-shi, Hokkaido, Japan

Takamatsu Red Cross Hospital /ID# 222875

🇯🇵

Takamatsu-shi, Kagawa, Japan

Mie University Hospital /ID# 213387

🇯🇵

Tsu-shi, Mie, Japan

Shinshu University Hospital /ID# 213408

🇯🇵

Matsumoto-shi, Nagano, Japan

Kansai Medical University Hospital /ID# 213388

🇯🇵

Hirakata-shi, Osaka, Japan

Nippon Medical School Hospital /ID# 213391

🇯🇵

Bunkyo-ku, Tokyo, Japan

Shizuoka General Hospital /ID# 224744

🇯🇵

Shizuoka-shi, Shizuoka, Japan

The Jikei University Hospital /ID# 213393

🇯🇵

Minato-ku, Tokyo, Japan

St.Luke's International Hospital /ID# 213392

🇯🇵

Chuo-ku, Tokyo, Japan

Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 213389

🇯🇵

Shinjuku-ku, Tokyo, Japan

Clinica Los Arcos Iztapalapa /Id# 216982

🇲🇽

Ciudad de México, Ciudad De Mexico, Mexico

Grupo Clinico Catei Sociedad Civil /Id# 216978

🇲🇽

Guadalajara, Jalisco, Mexico

Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 216979

🇲🇽

Mexico City, Mexico

Neki Servicios Medicos Profesionales S D Rl de Cv /Id# 216977

🇲🇽

Toluca, Mexico

Hospital Royo Villanova /ID# 231665

🇪🇸

Zaragoza, Spain

Laurentius Ziekenhuis /ID# 230503

🇳🇱

Roermond, Limburg, Netherlands

Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 225415

🇵🇱

Warszawa, Mazowieckie, Poland

Haaglanden Medisch Centrum /ID# 232063

🇳🇱

Den Haag, Netherlands

Medisch Centrum Leeuwarden /ID# 215779

🇳🇱

Leeuwarden, Netherlands

KSW nr1 w Rzeszowie /ID# 225444

🇵🇱

Rzeszow, Podkarpackie, Poland

Spitalul Clinic Colentina /ID# 224810

🇷🇴

Bucuresti, Romania

Spitalul Clinic Colentina /ID# 214307

🇷🇴

Bucuresti, Romania

Spitalul Clinic Județean de Urgențe "Sfântul Spiridon" /ID# 214335

🇷🇴

Jassi, Romania

King Saud University Med City /ID# 219065

🇸🇦

Riyadh, Saudi Arabia

Security Forces Hospital /ID# 221073

🇸🇦

Riyadh, Saudi Arabia

Hospital de Manacor /ID# 225083

🇪🇸

Manacor, Balears, Spain

Hospital Clínico Universitario de Santiago-CHUS /ID# 225076

🇪🇸

Santiago de Compostela, A Coruna, Spain

Hospital Universitario de Puerto Real /ID# 225103

🇪🇸

Puerto Real, Cadiz, Spain

Hospital Universitari Son Espases /ID# 233286

🇪🇸

Palma de Mallorca, Illes Balears, Spain

Hospital Santa María del Rosell /ID# 225100

🇪🇸

Cartagena, Murcia, Spain

Hospital Alvaro Cunqueiro CHUVI /ID# 225077

🇪🇸

Vigo, Pontevedra, Spain

Hospital Universitario de Bajadoz /ID# 225091

🇪🇸

Badajoz, Spain

Hospital Universitario Virgen de las Nieves /ID# 225107

🇪🇸

Granada, Spain

Hospital Juan Ramon Jimenez /ID# 225105

🇪🇸

Huelva, Spain

Hospital de Leon /ID# 226559

🇪🇸

Leon, Spain

Hospital Universitario Lucus Augusti /ID# 233282

🇪🇸

Lugo, Spain

Hospital San Telmo /ID# 233283

🇪🇸

Palencia, Spain

Hospital Clinico Universitario Lozano Blesa /ID# 231663

🇪🇸

Zaragoza, Spain

Hospital Universitario Virgen de Valme /ID# 225104

🇪🇸

Sevilla, Spain

Hospital Universitario 12 de Octubre /ID# 238474

🇪🇸

Madrid, Spain

Hospital Universitario de Salamanca /ID# 225078

🇪🇸

Salamanca, Spain

Hospital Universitario Ramon y Cajal /ID# 225093

🇪🇸

Madrid, Spain

Hospital Virgen de la Concha /ID# 233285

🇪🇸

Zamora, Spain

Hospital Universitario Miguel Servet /ID# 225080

🇪🇸

Zaragoza, Spain

Waldhotel Health & Medical Excellence /Id# 212743

🇨🇭

Obburgen, Nidwalden, Switzerland

Haut. Venen. Allergie. Zentrum Brunnehof /ID# 212742

🇨🇭

Uster, Zuerich, Switzerland

University Hospital Zurich /ID# 216539

🇨🇭

Zurich, Zuerich, Switzerland

Inselspital, Universitaetsspital Bern /ID# 212741

🇨🇭

Bern, Switzerland

Mediclinic Khalifa Branch /ID# 217871

🇦🇪

Abu Dhabi, United Arab Emirates

Mediclinic Welcare Hospital /ID# 223683

🇦🇪

Dubai, United Arab Emirates

Imperial College London - St Mary's Hospital /ID# 215978

🇬🇧

London, London, City Of, United Kingdom

Addenbrooke's Hospital /ID# 215972

🇬🇧

Cambridge, Cambridgeshire, United Kingdom

Frimley Health NHS Foundation Trust /ID# 215976

🇬🇧

Camberley, Surrey, United Kingdom

West Suffolk Hospital /ID# 249283

🇬🇧

Bury St Edmunds, Suffolk, United Kingdom

The Dudley Group NHS Foundation Trust /ID# 215839

🇬🇧

Dudley, United Kingdom

Ulster Hospital - South Eastern Health & Social Care Trust /ID# 215477

🇬🇧

Belfast, United Kingdom

NHS Lothian /ID# 249287

🇬🇧

Edinburgh, United Kingdom

Northern Care Alliance NHS Group /ID# 218589

🇬🇧

Manchester, United Kingdom

York and Scarborough Teaching Hospitals NHS Foundation Trust /ID# 227940

🇬🇧

York, United Kingdom

Sandwell and West Birmingham Hospitals NHS Trust /ID# 249294

🇬🇧

Lyndon, United Kingdom

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 215479

🇬🇧

Newcastle upon Tyne, United Kingdom

Winnipeg Clinic /ID# 212134

🇨🇦

Winnipeg, Manitoba, Canada

Skin Health Institute Inc /ID# 217619

🇦🇺

Carlton, Victoria, Australia

Beacon Dermatology Inc /ID# 213524

🇨🇦

Calgary, Alberta, Canada

University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 213507

🇨🇦

Vancouver, British Columbia, Canada

Dr. Irina Turchin PC Inc. /ID# 212128

🇨🇦

Fredericton, New Brunswick, Canada

Karma Clinical Trials /ID# 213522

🇨🇦

St. John's, Newfoundland and Labrador, Canada

NewLab Clinical Research Inc. /ID# 213521

🇨🇦

St. John's, Newfoundland and Labrador, Canada

SimcoDerm Medical and Surgical Dermatology Center /ID# 213081

🇨🇦

Barrie, Ontario, Canada

Healthy Medical Center S.A.S /ID# 231909

🇨🇴

Zipaquirá, Cundinamarca, Colombia

Centro Dermatologico Del Country S de Rl de Cv /Id# 225460

🇲🇽

Guadalajara, Jalisco, Mexico

Radboud Universitair Medisch Centrum /ID# 213592

🇳🇱

Nijmegen, Gelderland, Netherlands

Hospital Universitario Puerta de Hierro - Majadahonda /ID# 225084

🇪🇸

Majadahonda, Madrid, Spain

Universitätsspital Basel /ID# 212744

🇨🇭

Basel Town, Basel-Stadt, Switzerland

Cwm Taf Morgannwg University Health Board /ID# 215974

🇬🇧

Bridgend, Wales, United Kingdom

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