Comparison of the effect of ephedrine, ketamine, ondansetron and atropine drugs to prevent nausea and vomiting during and after surgery in patients under spinal anesthesia
Phase 2
- Conditions
- Postoperative nausea and vomiting.Nausea and vomiting
- Registration Number
- IRCT20230713058769N1
- Lead Sponsor
- Arak University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 128
Inclusion Criteria
Age 18-75 years old
Both genders
ASA class 1 and 2
Lower limb fracture repair surgery under spinal anesthesia
Consent to participate in the study
Exclusion Criteria
History of drug addiction
History of seasonal allergies and allergies to any of the drugs used in this study
Presence of neuromuscular diseases
Presence of cardiomyopathy
Presence of coagulopathy
Presence of an underlying disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vomiting score according to the vomiting score table. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Number of times nausea occurs. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Severity of nausea according to visual analogue scale. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Visual Analogue Scale.
- Secondary Outcome Measures
Name Time Method The degree of sedation according to the RAMSAY SCORE. Timepoint: In recovery and 1, 2 and 4 hours after the operation. Method of measurement: RAMSAY SCORE.;Dosage of Metoclopramide. Timepoint: Within 24 hours after the operation. Method of measurement: Patient file.