Prevention of Atrial Arrhythmias by Infusion of Magnesium Sulphate after Lung Resection for Cancer

Completed

• Conditions: Cancer: Lung; Cancer; Lung

• Registration Number: ISRCTN01500324
• Lead Sponsor: Record Provided by the NHSTCT Register - 2007 Update - Department of Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-09-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 240

Inclusion Criteria

240 subjects will be recruited. The investigator will be responsible for screening all patients listed for lung surgery at the CTC. Evidence from Terzi et al [32], had demonstrated that incidences of AF occurred in 10.7% of patients on magnesium sulphate as compared with 26.7% of control patients. We predict that at 90% power (2-sided ¿=0.05), 240 patients allowing for drop outs, deaths etc) are required to detect at least a 16% reduction in incidences of AF. Inclusion Criteria:
1. Elective for non-cardiac thoracic operations for lung cancer (lobectomy and pneumonectomy)
2. Ability to provide informed consent

Exclusion Criteria

1. Patients not undergoing major lung resection (see above)
2. Impaired renal function, preoperative creatinine >200 mol/L
3. Myocardial infarction within the last 6 months
4. Urgent or emergency operations
5. Video assisted thoracic surgery
6. Currently on drugs with antiarrhythmic properties
7. Patients with a history of preoperative cardiac arrhythmias

Study & Design

• Study Type: Interventional
• Study Design: Not specified