Study on clinical and radiological comparison of Demineralized Freeze Dried Bone Allograft alone and Demineralized Freeze Dried Bone Allograft with Hyaluronic acid in the treatment of periodontal bony defects.
- Conditions
- Chronic periodontitis,
- Registration Number
- CTRI/2020/07/026464
- Lead Sponsor
- ramya gattu self
- Brief Summary
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|The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue. The most common form of regenerative periodontal therapy is the use of bone grafts. Bone grafting materials function as structural scaffolds and matrices for attachment and proliferation of anchorage-dependent osteoblasts. Although autograft procedures fulfill many of the characteristics of an ideal bone graft material, autografts are more invasive due to the additional surgical manipulations required to obtain donor tissue, and are limited by the relatively small quantity of bone that can be obtained from such techniques.
One of the commonly used grafts is Demineralized Freeze-Dried Bone Allograft (DFDBA). Demineralization of a bone allograft exposes bone morphogenetic proteins within the bone matrix. These inductive proteins induce a cascade of events leading to cellular differentiation and the formation of bone through osteoinduction by inducing pleuripotential stem cells to differentiate into osteoblasts.
Hyaluronic acid (HA) is an essential component of extracellular matrix. It is a natural occurring linear polysaccharide of the extracellular matrix of connective tissue, synovial fluid, and other tissues. Hyaluronic acid structure consists of polyanionic disaccharide units of glucouronic acid and N-acetyl-glucosamine connected by alternating β 1–3 and β1–4 bonds. Hyaluronic acid interacts with other macromolecules and plays a predominant role in tissue morphogenesis, cell migration and adhesion . Hyaluronic acid has a primary role in the principal biological processes such as cell organization and differentiation. There is no anti-genic speciï¬city for species or tissue and thus, these agents have a low potential for allergic or immunogenic reaction. Hyaluronic acid has been implicated in cell–cell interaction, cell–matrix adhesion, cell motility, and the ordering of extracellular matrix.
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|Exogenous hyaluronic acid improved microcirculatory perfusion at the site of tissue repair in the wound area, and accelerated wound closure. When in close contact with bone, hyaluronic acid participates in bone morphogenesis and the early osteogenic events modulating the effects of several cytokines and growth factors. It also induces bone formation similar to osteogenic substrates such as calcitonin and bone morphogenic protein.
Scientific research on hyaluronic acid along with allografts are sparse. Hence, this study is designed to observe the potential of Hyaluronic Acid (HA) as a co-adjuvant of grafting processes to produce bone-like tissue in the presence of employing allograft(DFDBA) obtained in order to treat infra-bone defects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 36
- Age group is 18-55 years.
- Minimum 20 permanent teeth should be present 3.
- Periodontal pocket depth ≥ 5mm.
- Evidence of angular defects as determined by IOPA.
- Systemically compromised patients and those on medications (corticosteroids/ Bisphosphonate) that may interfere with wound healing.
- Pregnant women and lactating mother.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Gingival index baseline,6 months 2.Probing pocket depth baseline,6 months 3.Clinical attachment level baseline,6 months 4.Intrabony defect fill baseline,6 months
- Secondary Outcome Measures
Name Time Method Gingival healing index baseline, 6 months
Trial Locations
- Locations (1)
Department of Periodontics
🇮🇳Nalgonda, TELANGANA, India
Department of Periodontics🇮🇳Nalgonda, TELANGANA, IndiaDr RAMYA GATTUPrincipal investigator9676833105manjula72gattu@gmail.com