Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Osteoarthritis
• Interventions: Drug: saline; Drug: triamcinolone acetonide

• Registration Number: NCT00746889
• Lead Sponsor: University of California, San Diego

Brief Summary

A study using characteristics on ultrasound to predict response to intraarticular steroid injections in patients with knee osteoarthritis. The hypothesis is that patients with inflammation on ultrasound will have a better response to corticosteroid injections compared to patients without inflammation.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-03
• Primary Completion: 2008-07
• Status Verified: 2008-09
• Study Completion: 2008-09
• Study First Submitted: 2008-09-03
• Study First Submitted QC: 2008-09-03
• Study First Posted: 2008-09-04
• Results First Submitted: 2010-04-05
• Results First Submitted QC: 2010-07-29
• Last Update Submitted: 2010-07-29
• Results First Posted: 2010-08-25
• Last Update Posted: 2010-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

• knee pain
• diagnosis of osteoarthritis in affected knee

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Exclusion Criteria

• intraarticular corticosteroids in affected knee within past three months
• primary inflammatory connective tissue disease (ie rheumatoid arthritis)
• currently taking oral corticosteroids

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Injection	saline	Intraarticular injection of 0.9% saline
Corticosteroid Injection	triamcinolone acetonide	40 mg of intraarticular triamcinolone acetonide

Primary Outcome Measures

Name	Time	Method
Change in Western Ontario and McMasters Universities Arthritis Index (WOMAC) Pain Subscale	baseline to 4 weeks	WOMAC pain subscale range 0-20 (0=best, 20=worst)

Trial Locations

Locations (2)

University of California San Diego Medical Center; 🇺🇸 La Jolla, California, United States

San Diego VA Hospital; 🇺🇸 La Jolla, California, United States