Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients

Not Applicable

Terminated

• Conditions: Corneal Ulcer
• Interventions: Procedure: NSS/Lidocaine; Procedure: Lidocaine/NSS

• Registration Number: NCT00789646
• Lead Sponsor: Mahidol University

Brief Summary

The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2008-11-11
• Study First Submitted QC: 2008-11-11
• Study First Posted: 2008-11-13
• Primary Completion: 2008-12
• Study Completion: 2009-06
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-10
• Last Update Posted: 2019-03-12

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features.

  1. corneal epithelial defect with stromal infiltration
  2. reaction in anterior chamber
  3. positive for bacteria or fungus

• The patients have to receive subconjunctival antibiotic injection twice at least.

• The patients must be informed consent.

Exclusion Criteria

• The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs.
• The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection.
• Unable to cooperate with the treatment.
• Pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
NSS/Lidocaine	NSS/Lidocaine	First injection: Normal saline Second injection: 2% Lidocaine without adrenaline
Lidocaine/NSS	Lidocaine/NSS	First injection: 2% Lidocaine without adrenaline Second injection: Normal saline

Primary Outcome Measures

Name	Time	Method
Numeric rating scale	immediately after injection

Secondary Outcome Measures

Name	Time	Method
Side effects	24 hours after injection