Feasibility and preliminary effectiveness of a preoperative training and nutrition intervention in people with sarcopenic obesity who receive total hip or knee arthroplasty within the 'Actief Herstel' care pathway

Completed

Conditions: sarcopene obesitas
Sarcopenic obesity / Muscle weakness and overweight
10023213
10005944

Registration Number: NL-OMON49062

Lead Sponsor: Ziekenhuisvoorzieningen Gelderse Vallei

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 33

Inclusion Criteria

• Scheduled for THA or TKA with a waiting period of minimal 6 weeks (which is
the usual waiting period)
• Osteoarthritis as reason for surgery
• Having obesity (BMI >=30 kg/m2)
• Having muscle weakness (Men: Hand Grip Strength (HGS) <27kg; Women: HGS <16kg
or Chair stand >15sec for five rises)
• Adequate cognitive functioning (the patient is capable to understand
instructions and to per-form the screening)
• Age 18 years or older

Exclusion Criteria

Patient
• unable to understand Dutch;
• diagnosed with dementia;
• who are unable to exercise due to comorbidities/ contra-indications. Absolute
contra-indications for exercise are listed in the Dutch guideline for
osteoarthritis and in the ACSM's Guidelines for Exercise Testing and
Prescription;
• with severe renal insufficiency or an eGFR<30 (estimated Glomerular
Filtration Rate)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Feasibility is assessed by adherence to treatment, inclusion rates, drop out<br /><br>rates and adverse events and complications.<br /><br>The amount of attended training sessions attended and the achieved intensity<br /><br>are noted. The physical activity (accelerometer) and food intake (food diary)<br /><br>are also measured.<br /><br>The appreciation and motivation of the patient will be assessed with<br /><br>questionnaires.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Effectiveness is assessed by measuring physical functioning (timed up and go<br /><br>test, hand grip strength, walking speed/ six-minute walk test, chair rise time<br /><br>test, questionnaires), body composition (BIA/ DEXA) and inflammation (IL-6),<br /><br>before and after 6 weeks of intervention.<br /><br>In addition, postoperative inpatient complications, CRP, recovery of physical<br /><br>functioning and length of hospital stay will be assessed.<br /><br>Furthermore, nutritional intake (3-day food diary) and physical activity (by<br /><br>accelerometer) will be measured.</p><br>