Cytokine Profiling Post-Heart Transplant
Terminated
- Conditions
- Cardiac Transplant
- Registration Number
- NCT01643564
- Lead Sponsor
- University of Minnesota
- Brief Summary
Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
Group 1
- 18 years and older
- Cardiac Transplant recipient with graft dysfunction of unknown etiology
Group 2
- 18 years or older
- No history of heart failure or cardiac transplantation Group 3
- 18 years or older
- Class II-IV heart failure Group 4
- 18 years or older
- Heart Transplant 6 months or greater prior to blood draw
- No graft dysfunction
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Exclusion Criteria
Group 1 Heart Transplant with Unexplained Graft Dysfunction
- Cellular or antibody-mediated cardiac allograft dysfunction
Group 2 Normal Control group
- Active infection within 1 month of blood draw
- Known Inflammatory Disease
Group 3 Heart Failure Group
- Active infection within 1 month of blood draw
- Known Inflammatory Disease
Group 4 Heart Transplant with Normal Graft Function Group
- Active infection within 1 month of blood draw
- Known graft dysfunction
- Known Inflammatory Disease
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in cytokine profiles between stable heart transplant recipients and those with acute rejection 12 months Differences in cytokine profiles between stable heart transplant recipients and those with acute rejection
- Secondary Outcome Measures
Name Time Method