Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD
Completed
- Conditions
- Chronic Graft-versus-host Disease
- Registration Number
- NCT02411474
- Lead Sponsor
- Yonsei University
- Brief Summary
Investigate the profiles of tear cytokines in patients who underwent stem cell transplantation (SCT) and attempted to determine the applicability of tear cytokines in the diagnosis of chronic graft-versus-host disease (GVHD). Evaluate tear cytokines as biomarkers of chronic ocular GVHD severity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
- The patients patients aged 20-60 years who visited the clinic 3-12 months after SCT were included in the study.
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Exclusion Criteria
- The patients with histories of ocular surgery; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease, as well as patients with long-term use of topical ocular medications except artificial tears.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method tear cytokine 3-12 month after SCT comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay
tear film break-up time 3-12 month after SCT ocular surface disease index 3-12 month after SCT ocular surface status 3-12 month after SCT conjunctival injection 3-12 month after SCT Schirmer's test I 3-12 month after SCT
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Ophthalmology
🇰🇷Seoul, Korea, Republic of